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  • Microbiologist to join Rockefeller faculty | Newswire
    CRISPR array is often DNA that has been incorporated from bacteriophage viruses which invade bacteria or conjugative plasmids independent DNA molecules that are transferred between bacteria CRISPR plays a role in determining whether or not these DNA molecules become part of the bacterial genome it has the power to block bacteriophage infection and plasmid conjugation Marraffini says My goal is to figure out how they do this I want to tackle the phenomenon using a variety of techniques in biochemistry and genetics in order to figure out what are the important genes and protein machinery for this mechanism to work Not only would insight into CRISPR s mechanism suggest ways in which bacterial evolution could be manipulated blocking adaptations that would allow deadly pathogens to resist drugs but the mechanism itself could potentially be harnessed to create useful genetically engineered bacteria A better understanding of CRISPR would also allow scientists to better interpret the historical record of past phage and plasmid infections contained within the bacteria s DNA shedding light on how they have developed over millions of years Luciano is an excellent microbiologist trying to understand how bacteria can be such adaptable organisms says Paul Nurse the university s president His work has shown us how they are able to borrow DNA from other organisms in order to fight their infection and understanding more about this process will ultimately lead to new ways of battling infectious disease Marraffini a native of Argentina received his undergraduate degree from the University of Rosario in Argentina and his Ph D in microbiology from the University of Chicago in 2007 He then moved to Northwestern University where he is currently a postdoc sponsored by the Jane Coffin Childs Memorial Fund As a postdoctoral fellow he was the first to demonstrate that CRISPR can

    Original URL path: http://newswire.rockefeller.edu/2010/06/18/microbiologist-to-join-rockefeller-faculty/ (2016-02-13)
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  • Luciano Marraffini and Robert Roeder recognized by ASBMB awards | Newswire
    make CRISPR immunity possible as well as the evolutionary implications of this bacterial immunity to viruses while exploring potential applications for CRISPR Cas systems He shares the Stadtman Award with biological chemist Georgios Skiniotis from the University of Michigan The award recognizes scientists with 10 or fewer years of postdoctoral experience and includes a 10 000 cash prize and travel expenses for the ASBMB annual meeting A native of Argentina Marraffini received his Ph D in microbiology in 2007 from the University of Chicago and completed his postdoc at Northwestern University before joining Rockefeller s faculty in 2010 His recent honors include being chosen by Cell as one of its 40 Under 40 named a Blavatnik National Award Finalist and receiving an Investigators in the Pathogenesis of Infectious Disease award from the Burroughs Wellcome Foundation Robert Roeder wins the Herbert Tabor Research Award Roeder the Arnold and Mabel Beckman Professor and head of the Laboratory of Biochemistry and Molecular Biology studies the molecular mechanisms that regulate transcription the process by which genes are copied into RNA for translation into protein His major object is to determine how cell specific master transcription factors act upon the molecular machinery responsible for transcription to activate or repress specific target genes Roeder is the recipient of the Tabor Award which recognizes excellence in biological chemistry and molecular biology as well as contributions to the community of scientists It includes 30 000 for research a plaque and travel expenses for the ASBMB annual meeting Roeder received his Ph D in biochemistry from the University of Washington in 1969 and did his postdoc at the Carnegie Institution of Washington He joined the faculty of Washington University School of Medicine in 1971 and came to Rockefeller as a professor in 1982 His numerous awards include the Canada

    Original URL path: http://newswire.rockefeller.edu/2015/08/13/luciano-marraffini-and-robert-roeder-recognized-by-asbmb-awards/ (2016-02-13)
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  • ASBMB | Newswire
    genome editing has won the Earl and Thressa Stadtman Scholar Award Meanwhile Robert Roeder who investigates the mechanisms that regulate transcription the process by which genes are copied into RNA is the recipient of the Herbert Tabor Research Award More Tags ASBMB awards and honors Laboratory of Bacteriology Laboratory of Biochemistry and Molecular Biology Luciano Marraffini Robert Roeder Search for Categories Science News Awards and Honors Campus News Grants Gifts

    Original URL path: http://newswire.rockefeller.edu/tag/asbmb/ (2016-02-13)
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  • awards and honors | Newswire
    in genome editing has won the Earl and Thressa Stadtman Scholar Award Meanwhile Robert Roeder who investigates the mechanisms that regulate transcription the process by which genes are copied into RNA is the recipient of the Herbert Tabor Research Award More Tags ASBMB awards and honors Laboratory of Bacteriology Laboratory of Biochemistry and Molecular Biology Luciano Marraffini Robert Roeder Search for Categories Science News Awards and Honors Campus News Grants

    Original URL path: http://newswire.rockefeller.edu/tag/awards-and-honors/ (2016-02-13)
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  • Luciano Marraffini selected as a Blavatnik National Award finalist | Newswire
    scientific innovators have honored scientists in the New York City area Beginning in 2014 the Blavatnik Family Foundation and the New York Academy of Sciences which administers the awards expanded the faculty portion of the program to include young scientists across the United States The national awards have three categories life sciences physical sciences and engineering and chemistry Each year one finalist in each category will be awarded 250 000 in unrestricted funds CRISPR Cas systems the focus of Marraffini s work make it possible for bacteria and other microbes to acquire immunity against viruses by capturing snippets of their DNA Dr Marraffini investigates the molecular mechanisms that make CRISPR immunity possible as well as its evolutionary implications His lab also explores potential applications for CRISPR Cas systems which can be used to make precisely targeted cuts in any genome Luciano s work has illuminated new nuances in the ongoing war between bacteria and the viruses that infect them as well as suggested potentially powerful biotechnological applications such as antibiotics that selectively target harmful microbes says Marc Tessier Lavigne the university s president I am proud to see Luciano recognized for this important work by the Blavatnik Foundation Marraffini a native of Argentina received his undergraduate degree from the University of Rosario in Argentina and his Ph D from the University of Chicago in 2007 He was a postdoc at Northwestern University from 2008 to 2010 when he joined Rockefeller as assistant professor In 2014 Cell named him one of its 40 Under 40 He is a 2012 Rita Allen Foundation Scholar and a 2011 Searle Scholar and is the recipient of a 2012 NIH Director s New Innovator Award a 2010 RNA Society Award a 2009 Nestle Award and a 2008 Jane Coffin Childs Memorial Fund for Medical Research

    Original URL path: http://newswire.rockefeller.edu/2015/05/22/luciano-marraffini-selected-as-a-blavatnik-national-award-finalist/ (2016-02-13)
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  • Blavatnik National Award | Newswire
    who studies the CRISPR Cas systems that enable some bacteria to acquire immunity against viruses is among 32 highly qualified young faculty researchers selected to compete for this national award More Tags Blavatnik Awards Blavatnik National Award Laboratory of Bacteriology Luciano Marraffini Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The Rockefeller

    Original URL path: http://newswire.rockefeller.edu/tag/blavatnik-national-award/ (2016-02-13)
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  • Five Rockefeller scientists receive high risk-high reward NIH grants | Newswire
    tackle problems with new and transformative approaches says Marc Tessier Lavigne the university s president We re proud to have a record number of Rockefeller faculty receiving these esteemed grants this year The Transformative Award was established in 2009 to promote interdisciplinary research on as yet untested ideas research that has the potential to create or overturn fundamental paradigms Darnell is a Howard Hughes Medical Institute investigator the senior attending physician at The Rockefeller University Hospital and the Robert and Harriet Heilbrunn Professor in the Laboratory of Molecular Neuro oncology His lab focuses on understanding a group of rare brain diseases the paraneoplastic neurologic disorders and how they arise in conjunction with immune responses to cancer The Transformative Award will support Darnell s study of the dysregulation of RNA which is increasingly recognized to lie at the root of many human neurologic diseases using a breakthrough technology developed in his lab called HITS CLIP and a new method synaptic translational profiling The studies could bring new insight into degenerative diseases of memory such as Alzheimer s Tuschl also a Howard Hughes Medical Institute investigator and head of the Laboratory of RNA Molecular Biology investigates gene regulatory mechanisms that are triggered by double stranded RNA and RNA binding proteins mostly in human cells with the goal of developing a new generation of therapeutic treatments for genetic diseases The award will fund his research into the interaction network of mRNA binding transport and shuttling proteins and his effort to establish theoretical and experimental models that relate these mechanisms to RNA transport processes and post transcriptional gene regulation He ll work with structural biologist Dinshaw Patel of Memorial Sloan Kettering Cancer Center and computational biologist Uwe Oehler from Duke University on the project The New Innovator Award was created in 2007 with the purpose of supporting investigators who are within 10 years of their terminal degree or clinical residency but who have not yet received a Research Project Grant or equivalent NIH grant to conduct exceptionally innovative research Kronauer is head of Laboratory of Insect Social Evolution and joined Rockefeller as assistant professor in 2011 His lab uses insects which like humans are highly responsive to their social environment to study the effects of social interactions on individual behavior and physiology The innovator award will support Kronauer s efforts to develop the ant Cerapachys biroi as a novel genetic model system to study the molecular components that enable individuals to function as a society and to examine how those components are derived from the genetic architecture of solitary ancestors Maimon joined Rockefeller as assistant professor in 2011 and is head of the Laboratory of Integrative Brain Function His work aims to link the electrical activity of neurons and the biochemical action of molecules to their computational roles in animal behavior His award will fund a project that examines how genes in fruit flies through their effect on the electrical activity of neurons influence behavioral choices with the goal of discovering general principles that

    Original URL path: http://newswire.rockefeller.edu/2012/09/13/five-rockefeller-scientists-receive-high-risk-high-reward-nih-grants/ (2016-02-13)
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  • high reward | Newswire
    University faculty have been awarded the NIH Director s Transformative Award and three are being given New Innovator Awards More Tags Daniel Kronauer Gaby Maimon high reward high risk Luciano Marraffini New Innovator Award NIH Pioneer Award Robert B Darnell Thomas Tuschl Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The Rockefeller

    Original URL path: http://newswire.rockefeller.edu/tag/high-reward/ (2016-02-13)
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