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  • New Innovator Award | Newswire
    Award Robert B Darnell Thomas Tuschl September 24 2009 Grants and Gifts New Innovator Award goes to cancer researcher Sohail Tavazoie One of Rockefeller s newest faculty recruits Tavazoie aims to identify small pieces of RNA known as microRNAs that may signal a high potential for metastasis or that can effectively distinguish between cancers that will be responsive to chemotherapy and those that would be better candidates for alternative and

    Original URL path: http://newswire.rockefeller.edu/tag/new-innovator-award/ (2016-02-13)
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  • NIH | Newswire
    grant that will allow him to establish his own research program at Rockefeller More Tags Brad Rosenberg Director s Award Early Independence NIH September 13 2012 Awards and Honors Five Rockefeller scientists receive high risk high reward NIH grants Two Rockefeller University faculty have been awarded the NIH Director s Transformative Award and three are being given New Innovator Awards More Tags Daniel Kronauer Gaby Maimon high reward high risk

    Original URL path: http://newswire.rockefeller.edu/tag/nih/ (2016-02-13)
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  • Pioneer Award | Newswire
    Darnell Thomas Tuschl September 29 2005 Awards and Honors Titia de Lange receives NIH Pioneer Award The National Insitutes of Health has selected Titia de Lange who examines how cells respond to DNA damage to receive up to 500 000 in direct costs per year for five years The prestigious Pioneer Award now in its second year supports groundbreaking high risk research that if successful will have a significant impact

    Original URL path: http://newswire.rockefeller.edu/tag/pioneer-award/ (2016-02-13)
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  • Robert B. Darnell | Newswire
    out of the limelight and gave way to RNA as a major player in genetic regulation New findings that reveal the master architect behind a functioning motor neuron not only mirror this ideological shift but further point to the increasingly indisputable role of RNA as the molecule behind biological complexity More Tags Neurons Robert B Darnell November 2 2008 Science News New method provides panoramic view of protein RNA interactions in living cells The postgenomic era has taught us a big one That the measure of human complexity has less to do with how many genes we have as it does with how we process them Now Rockefeller University scientists offer for the first time a genome wide view from the first chromosome to the last of how differences in RNA can explain how a worm and a human can each have 25 000 genes yet be so different More Tags HITS CLIP RNA Robert B Darnell November 3 2006 Science News RNA map gives first comprehensive understanding of alternative splicing Though scientists have begun to appreciate how alternative splicing adds a layer of complexity to brain processes that enable us to think and learn exactly how alternative splicing is regulated during these processes and in some cases is uncontrolled or dysregulated to cause disease has remained elusive A new map however provides the first comprehensive understanding of how alternative splicing works throughout the genome The results have implications for a better understanding of such brain functions as learning and memory neurological diseases and cancer biology More Tags RNA map Robert B Darnell October 19 2005 Science News A single protein is crucial to memory formation scientists show New findings show that a single protein called Nova is responsible for regulating the quality of the information that is processed in the spaces between brain cells More Tags Nova Robert B Darnell November 14 2003 Science News Researchers describe new technique for cataloging RNA targets in rare brain disease RNA often thought of as merely the chemical messenger that helps decode DNA s genetic instructions for making proteins can itself play a crucial role in regulating protein expression Not surprisingly this regulation occurs through proteins that bind to RNA All cells in the body especially nerve cells in the brain use and regulate RNA in an exquisite fashion More Tags CLIP micro Robert B Darnell May 28 2002 Awards and Honors Vanishing Breed of Researchers Recognized by HHMI Robert B Darnell M D Ph D whose bench to bedside studies at Rockefeller University have uncovered new insights about how the brain normally works and about tumor immunity is one of the 12 physician scientists selected for a new Howard Hughes Medical Institute HHMI program spotlighting the value of relating basic research discoveries to improving medical therapy More Tags Robert B Darnell November 16 2001 Science News Researchers Uncover Molecular Basis of Second Leading Cause of Mental Retardation Scientists at last may have determined how mental retardation develops in people with fragile

    Original URL path: http://newswire.rockefeller.edu/tag/robert-b-darnell/ (2016-02-13)
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  • Thomas Tuschl | Newswire
    Thomas Tuschl The university promotes a biochemist who researches RNA interference RNAi the process by which small RNA molecules interfere with gene expression More Tags RNA Thomas Tuschl January 22 2009 Science News New method prevents microRNAs from escaping cells Since their discovery microRNAs have been hailed as the stars of the RNA universe as they have been shown to play a role in countless diseases ranging from cancer to neurological disorders Now researchers at Rockefeller University have discovered a better more reliable way to detect and measure these tiny molecules work that may lead to improved ways of diagnosing and preventing disease More Tags John Pena MicroRNAs Thomas Tuschl September 5 2007 Science News A global view Researchers build microRNA atlas Rockefeller University scientists have created a comprehensive microRNA catalog that encompasses more than 250 cell and tissue samples across 26 organ systems as part of a global effort to clarify the role of microRNAs in development and in various diseases particularly cancer More Tags MicroRNAs Thomas Tuschl December 1 2006 Science News Newly discovered class of small RNAs is specifically to reproductive cells One size does not fit all when it comes to RNA Scientists have now discovered

    Original URL path: http://newswire.rockefeller.edu/tag/thomas-tuschl/ (2016-02-13)
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  • Atomic view of cellular pump reveals how bacteria send out proteins | Newswire
    that work alone or with two partner proteins in some bacteria they are the simplest such systems Each PCAT molecule has three domains each in duplicate one recognizes the cargo by a tag it carries and cuts off that tag another binds to and burns ATP a molecule that contains energy stored within its atomic bonds and the third forms a channel that spans the cells membrane Previous work had examined the structure of the first two domains but the structure of the third had remained a mystery along with the details of how the components function together At this point we have no idea how many PCATs exist although we expect they are numerous because each specializes in a specific type of cargo For this study we focused on one we called PCAT1 which transports a small protein of unknown function says first author David Yin wei Lin a postdoc in the lab To get a sense of how PCAT1 changes shape when powered by energy from ATP we examined the structure in two states both with and without ATP The team which also included Shuo Huang a research technician who is now a graduate student at Georgia Institute of Technology purified and crystalized the PCAT1 protein from the heat loving bacterium Clostridium thermocellum To determine the structure of the crystals they used a technique called X ray diffraction analysis in which a pattern produced by X rays bounced off the crystallized protein can be used to infer the structure of the molecule The first structure determined without ATP revealed a striking feature a large water filled central channel a natural environment for a water loving or hydrophilic protein Two side openings into this channel were guarded by the cargo recognizing domain acting as a sort of ticket taker

    Original URL path: http://newswire.rockefeller.edu/2015/07/22/atomic-view-of-cellular-pump-reveals-how-bacteria-send-out-proteins/ (2016-02-13)
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  • cellular pump | Newswire
    striking feature a large water filled channel a natural environment for the hydrophilic proteins that must pass through Their work offers new insight into the mechanics that allow bacteria to manipulate their environments More Tags cellular pump David Yin wei Lin Jue Chen Laboratory of Membrane Biology and Biophysics membrane protein PCAT protein transport Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/tag/cellular-pump/ (2016-02-13)
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  • David Yin-wei Lin | Newswire
    a striking feature a large water filled channel a natural environment for the hydrophilic proteins that must pass through Their work offers new insight into the mechanics that allow bacteria to manipulate their environments More Tags cellular pump David Yin wei Lin Jue Chen Laboratory of Membrane Biology and Biophysics membrane protein PCAT protein transport Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/david-yin-wei-lin/ (2016-02-13)
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