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  • t cells | Newswire
    fast responding immune system cell called the natural killer T NKT cell in patients with advanced cancer The study surprised researchers by revealing the ability of these NKT cells to spur other slower responding immune cells to go to work More Tags Madhav Dhodapkar NKT t cells vaccines December 17 2004 Science News Novel cellular pathway increases sensitivity of body s immune detectives In the Dec 9 issue of Scientists at Rockefeller University report the discovery of a previously unknown pathway that boosts the ability of helper T cells to motivate killer T cells in detecting and attacking dangerous cells The finding may help scientists to create a more effective immune response against disease and tumor formation More Tags Christian Munz t cells March 19 2004 Science News Immunity runs amok without Csk Inflammation is emerging as a new window on chronic diseases such as cancer heart ailments and autoimmunity Two Rockefeller University scientists have recently revealed one of the molecular keys to inflammation Their discovery may help clinicians understand shortcomings in the inflammatory response that lead to potentially life threatening conditions More Tags Csk Sasha Tarakhovsky t cells February 2 2004 Science News Natural killer cells are made not born For years scientists regarded natural killer cells as a blunt instrument of the body s immune defense system Born to kill these cells were thought to travel straight from the bone marrow where they are manufactured to the blood circulating there and infiltrating the sites of early tumors or infectious agents in the body Now Rockefeller University scientists led by Christian Münz Ph D have learned otherwise More Tags cell activation Christian Munz t cells October 10 2001 Science News Rockefeller Researchers Discover Possible Trigger for Killer T Cells To Attack How do killer T cells know when to

    Original URL path: http://newswire.rockefeller.edu/tag/t-cells/ (2016-02-13)
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  • Howard Hang promoted to associate professor | Newswire
    how successful pathogens subvert these host defense mechanisms Since microbial pathogens interact with host membranes during infection he focused on posttranslational modifications that regulate the activity of membrane proteins in immune cells By developing innovative chemical biology methods his laboratory has discovered that many proteins involved in host immunity to viruses and bacteria are regulated by fatty acid modifications We are very excited about these discoveries which suggests that the strength and specificity of immune responses may be directly linked to fatty acid metabolism and protein modification says Hang He has since been working on how the attachment of fatty acids to proteins is regulated in immune cells and determining whether microbial pathogens interfere with this important lipid modification during infection to cause disease Looking ahead Dr Hang hopes to identify specific host and pathogen factors that regulate fatty acid modifications and develop new strategies to control immune responses to harmful microbes Howard s work has shed new light on some of what occurs behind the scenes when the immune system responds to pathogens such as influenza viruses and salmonella says Marc Tessier Lavigne the university s president His discoveries have opened up a new line of inquiry that may turn out to have important implications in immunology and microbiology I look forward to seeing where this research leads as Howard embarks on the next chapter of his career Dr Hang trained as a chemist received his undergraduate degree from the University of California Santa Cruz and his Ph D from the University of California Berkeley with Carolyn Bertozzi As a postdoc he worked on innate and adaptive immunity under Hidde Ploegh at the Harvard Medical School and at the Whitehead Institute for Biomedical Research Dr Hang is a recipient of the Irma T Hirschl Monique Weill Caulier Trust Research

    Original URL path: http://newswire.rockefeller.edu/2013/03/25/howard-hang-promoted-to-associate-professor/ (2016-02-13)
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  • Howard Hang | Newswire
    by fatty acid modifications More Tags Howard Hang immunology microbiology August 21 2006 Campus News Chemical immunologist recruited to head new Rockefeller lab A faculty search process begun last year has yielded its second successful recruit the chemical immunologist Howard Hang who will join Rockefeller University as assistant professor and head of the Laboratory of Chemical Biology and Microbial Pathogenesis in early 2007 More Tags Howard Hang Search for Categories

    Original URL path: http://newswire.rockefeller.edu/tag/howard-hang/ (2016-02-13)
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  • Jean-Laurent Casanova | Newswire | Page 2
    with a rare autoimmune disorder known as APS 1 By pinpointing the cause of candidiasis in these patients the finding paves the way for treating these fungal infections with drugs that are already out in the market More Tags Jean Laurent Casanova Laboratory of Human Genetics of Infectious Diseases December 17 2009 Science News Mutation leads to new and severe form of bacterial disease Everybody gets sick but how sick you get is in your genes New research now reveals a mutation on a gene that makes children susceptible to a severe form of mycobacterial disease The work not only supports a controversial idea that certain genes evolved to combat specific bacteria but also reveals new mechanistic details of how the immune system fights off one of the planet s fiercest pathogens More Tags Jean Laurent Casanova Laboratory of Human Genetics of Infectious Diseases Mycobacterium July 21 2008 Campus News Clinical immunologist to join Rockefeller University Jean Laurent Casanova a distinguished pediatrician and immunologist who comes from Hospital Necker for Sick Children in Paris will join the faculty at The Rockefeller University as professor of medicine and head of the Laboratory of Human Genetics of Infectious Diseases in September 2008

    Original URL path: http://newswire.rockefeller.edu/tag/jean-laurent-casanova/page/2/ (2016-02-13)
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  • In the News – Newsweek – Casanova | Newswire
    develop the anti infectious agents says Dr Jean Laurent Casanova a professor at Rockefeller University who studies how genetic coding can make a person more susceptible to disease If we continue to rely solely on antibiotics we are going to have a problem Tags antibiotic resistance antibiotics antibodies Jean Laurent Casanova newswire rockefeller edu Rockefeller University president Tessier Lavigne chosen to lead Stanford University Scientists learn how young brains form

    Original URL path: http://newswire.rockefeller.edu/2016/02/07/in-the-news-newsweek-casanova/ (2016-02-13)
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  • antibiotics | Newswire
    able to outwit them More Tags antibiotics Ceftobiprole MRSA June 4 2007 Science News Study of staph reveals how bacteria evolve resistance By studying blood taken from a single patient over a period of months Rockefeller University researchers have been able to trace how a common strain of bacteria adapted its genes to counteract the antibiotics used to try to kill it More Tags Alexander Tomasz antibiotics staph February 22 2006 Science News Genetic stress response may explain how bacteria resist drugs Bacteria have a nasty habit of developing resistance to even our most powerful pharmaceuticals But by tracking the staph infection of a single patient during a course of antibiotic treatment Rockefeller University scientists have discovered new clues to how bacteria evolve resistance More Tags Alexander Tomasz antibiotics drug resisitance Stress November 1 2005 Science News Bacteria build walls to withstand antibiotics Antibiotic resistant bacteria which are proliferating in hospitals and causing major headaches for physicians cheat death by finding ways to fortify their cell walls against the deadly drugs Now new research from the laboratory of Rockefeller s Alexander Tomasz shows that one gene called mecA enables them to this More Tags Alexander Tomasz antibiotics August 20 2004 Science News Viral locksmith is caught in the act How does the molecular machine responsible for activating genes choose which gene to switch on from among the 30 000 genes contained in each cell of the human body In the August 4 issue of the EMBO Journal researchers at Rockefeller University report that they are beginning to answer that question in bacteria and the answers are not only surprising but may also aid in the development of powerful new antibiotics More Tags antibiotics Milton H Werner March 5 2002 Science News Superbug Update Only a few families of Staphylococci cause most drug resistant diseases in hospitals worldwide The culprits behind antibiotic resistant diseases now plaguing hospitals worldwide have been harboring a secret one that Rockefeller scientists have recently exposed It seems these infectious microbes termed Staphylococcus aureus are not independent criminals working alone Rather they are members of only a few massive superbug families which have spread out and conquered the globe More Tags Alexander Tomasz antibiotics staph March 20 2001 Science News Researchers Find Novel Way to Kill Streptococci Bacteria Researchers at The Rockefeller University have discovered a powerful new way to destroy on contact the bacteria that cause strep throat flesh eating disease and a variety of other infections The technique which may not cause the bacteria to evolve resistant strains as antibiotics do also could have applications for many other bacterial diseases The findings are reported in the March 20 issue of Proceedings of the National Academy of Sciences Early Edition Issue No 12 More Tags antibiotics Strep Vincent A Fischetti February 18 1999 Science News Researchers Report Emergence of Antibiotic Resistance during Vancomycin Therapy A team of researchers led by The Rockefeller University s AlexanderTomasz Ph D have described the case of a 79 year old

    Original URL path: http://newswire.rockefeller.edu/tag/antibiotics/ (2016-02-13)
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  • Mutations in a single gene underlie vulnerability to two unrelated types of infections | Newswire
    to multiple problems within the immune system including interfering with the production of interferon γ which is crucial for fending off mycobacteria While the highest profile members of this group include the microbes responsible for tuberculosis and leprosy other mycobacteria are weak threats at best Inherited problems with interferon γ render the patients vulnerable to this latter group including live bacilli Calmette Guerin BCG vaccines used to inoculate against tuberculosis Indeed for people who carry rare genetic defects the BCG vaccine can cause severe even fatal illness Casanova works with physicians from around the world to collect samples from patients who suffer from BCG and other mycobacterial infections His lab then searches these patients genetic sequences for the mutations responsible for this vulnerability While examining the genome of the Palestinian child one of the first authors Satoshi Okada then a postdoc in the lab and now an assistant professor of pediatrics at Hiroshima University Graduate School of Biomedical Health Sciences found that this child carried two mutated copies of RORC RORC was known to control the production of cytokines called interleukin 17 by T cells which are important in mice and humans for host defense against yeasts known as Candida which infect the skin nails and mucous membranes Indeed the lab had previously shown that inborn errors of interleukin 17 immunity underlie chronic mucocutaneous candidiasis Work in mice revealed why this happens The protein encoded by RORC helps control the development of interleukin 17 producing T cells The RORC mutations seemed to explain the child s thrush an oral fungal infection but I was skeptical that these could be linked to the BCG infection that ultimately caused her death However after two other children in her extended family contracted similar infections I found sets of RORC mutations in each strongly suggesting a connection to the illnesses Okada says To understand the genetics of the disease it is important to note that the Palestinian children s parents were first cousins Such a relationship between parents puts their children at a high risk of inheriting two defective copies of the same gene and as a result suffering from extremely rare disorders The link between RORC and the mycobacterial vulnerability was confirmed in the genomes of one Chilean and three Saudi children also the offspring of consanguineous marriages who suffered from a similar combination of diseases Okada set about doing molecular experiments to assess the mutant proteins produced by the defective RORC genes The other first author Janet Markle a postdoc in the lab later took on this work and sought to link these molecular changes with the patients vulnerabilities to disease Collaborators in Australia Switzerland and Boston contributed to the experiments In these new experiments the researchers verified that the RORC mutations found in the patients dramatically decreased their ability to produce interleukin 17 They also pinned down a connection to interferon γ and as a result mycobacterial disease When looking at the immunological effects of the RORC mutations we found a

    Original URL path: http://newswire.rockefeller.edu/2015/07/09/mutations-in-a-single-gene-underlie-vulnerability-to-two-unrelated-types-of-infections/ (2016-02-13)
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  • Candida | Newswire
    susceptible to two very different diseases aggravating but treatable fungal infections as well as invasive and potentially fatal bacterial disease This finding suggests a dual role for that gene RORC in human immunity to infection More Tags Candida immune deficiency Janet Markle Jean Laurent Casanova mycobacteria Satoshi Okada St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/tag/candida/ (2016-02-13)
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