archive-edu.com » EDU » R » ROCKEFELLER.EDU

Total: 1631

Choose link from "Titles, links and description words view":

Or switch to "Titles and links view".
  • ISG15 | Newswire
    inflammation More Tags autoimmune disease Dusan Bogunovic interferon ISG15 Jean Laurent Casanova mycobacteria August 10 2012 Science News Protein proves vital in immune response to bacteria Research led by Rockefeller University scientists found that a protein once thought to be mainly involved in antiviral immunity is instead vital to fighting a type of bacteria that cause diseases such as tuberculosis and leprosy More Tags Dusan Bogunovic ISG15 Jean Laurent Casanova

    Original URL path: http://newswire.rockefeller.edu/tag/isg15/ (2016-02-13)
    Open archived version from archive


  • Jean-Laurent Casanova to receive 2014 Robert Koch Award | Newswire
    which he was awarded the 1905 Nobel Prize for Medicine and Physiology From 1891 until his retirement in 1904 Koch was Head of the Institute for Infectious Diseases in Berlin The Robert Koch Award is one of Germany s most distinguished scientific awards Casanova and Fischer are being honored for their groundbreaking work on understanding host genes and their products in infectious diseases Casanova is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens while most other children do not He and his colleagues have discovered holes in the immune systems of otherwise healthy children that make them susceptible to specific sometimes life threatening infectious diseases These holes are caused by congenital mutations in a single gene and are responsible for the susceptibility to certain infections including mycobacterial diseases herpes simplex virus encephalitis invasive pneumococcal disease chronic mucocutaneous candidiasis or Kaposi sarcoma The practical implementations of these findings include molecular diagnosis and genetic counselling for the patients and their families as well as the development of targeted therapies with recombinant cytokines aimed at restoring a deficient immune response Casanova has been at Rockefeller since 2008 and has been a Howard Hughes Medical Institute investigator since 2014 He is a member of the European Molecular Biology Organization and the American Society for Clinical Investigation Casanova was the recipient of the Professor Lucien Dautrebande Pathophysiology Foundation Prize from the Belgian Royal Academy of Medicine in 2004 the Richard Lounsbery Award from the French and American Academies of Sciences in 2008 the Oswald Avery Award from the Infectious Disease Society of America in 2009 the E Mead Johnson Award from the Society for Pediatric Research in 2010 the InBev Baillet Latour Foundation in Belgium in 2011 the Ilse and Helmut Wachter Foundation Award and the Milstein

    Original URL path: http://newswire.rockefeller.edu/2014/06/24/jean-laurent-casanova-to-receive-2014-robert-koch-award/ (2016-02-13)
    Open archived version from archive

  • awa | Newswire
    their products in infectious diseases His lab is interested in why some children develop severe infectious diseases after coming into contact with certain pathogens while most other children do not More Tags awa genetics infectious disease Jean Laurent Casanova St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About

    Original URL path: http://newswire.rockefeller.edu/tag/awa/ (2016-02-13)
    Open archived version from archive

  • A new web tool effectively prioritizes disease-causing genes by biological distance | Newswire
    project and a postdoc in the St Giles Laboratory of Human Genetics of Infectious Disease led by Jean Laurent Casanova Science project High school students Benjamin center and Mark right Mazel used their computer programming skills to help Postdoc Yuval Itan left improve the accessibility of the Human Gene Connectome a tool to help biologists make connections between genes It wasn t enough for the system to work we needed to make it widely accessible and we have accomplished that in part thanks to the efforts of two high school students Itan says The students Benjamin and Mark Mazel were placed in the lab through the university s Summer Science Research Program and spent their summer giving the system its more user friendly interface They are co authors of a paper published in BMC Genomics last week announcing the site s debut The biological distance metric generated by the system can implicate a single gene in a disease which is the goal of the Casanova laboratory Typically this process begins with a list of hundreds or thousands of candidate genes that carry mutations in a patient The investigator first looks for mutations in genes known to cause disease and if none are present which is often the case the next question is Which genes on this list belong to the same pathway or have a similar function as known disease causing genes The search often ends here since literature searches become overwhelming and other conventional tools are limited Itan and colleagues offered a new solution when they first described the Human Gene Connectome last year in the Proceedings of the National Academy of Sciences We can now take any two human genes and then navigate and measure the distance between the two of them by one click of a button

    Original URL path: http://newswire.rockefeller.edu/2014/04/14/a-new-web-tool-effectively-prioritizes-disease-causing-genes-by-biological-distance/ (2016-02-13)
    Open archived version from archive

  • human gene connectome | Newswire
    research program Yuval Itan March 18 2013 Science News Researchers create map of shortcuts between all human genes Researchers at Rockefeller University along with colleagues at Necker Hospital for Sick Children and the Pasteur Institute in Paris and Ben Gurion University in Israel have generated the full set of distances routes and degrees of separation between any two human genes creating a map of gene shortcuts that aims to simplify

    Original URL path: http://newswire.rockefeller.edu/tag/human-gene-connectome/ (2016-02-13)
    Open archived version from archive

  • summer science research program | Newswire
    Connectome an investigator can rank potential disease causing genes based on a new metric called biological distance This tool is now available online thanks in part to the work of two high school students More Tags human gene connectome Jean Laurent Casanova summer science research program Yuval Itan Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About

    Original URL path: http://newswire.rockefeller.edu/tag/summer-science-research-program/ (2016-02-13)
    Open archived version from archive

  • Yuval Itan | Newswire
    an investigator can rank potential disease causing genes based on a new metric called biological distance This tool is now available online thanks in part to the work of two high school students More Tags human gene connectome Jean Laurent Casanova summer science research program Yuval Itan Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact

    Original URL path: http://newswire.rockefeller.edu/tag/yuval-itan/ (2016-02-13)
    Open archived version from archive

  • Jean-Laurent Casanova appointed HHMI investigator | Newswire
    number of Rockefeller scientists supported by HHMI to 16 The new investigators who will begin their appointments in September represent 19 institutions across the United States and were selected from a pool of 1 155 applicants Though the investigators remain at their institutions HHMI will provide a full salary benefits and a research budget over their initial five year appointment The institute will also cover other expenses including research space and the purchase of critical equipment The investigators have the opportunity to renew their appointment for additional five year terms contingent on a successful scientific review This is a highly deserved honor for Jean Laurent whose research on the genetics of pediatric infectious diseases has had a tremendous impact on fundamental immunology says Marc Tessier Lavigne Rockefeller s president As an HHMI investigator Jean Laurent will have even greater opportunities to push the boundaries of immunological research and the university looks forward to seeing the exciting initiatives his lab will take from here Casanova s research centers on identifying genetic mutations that predispose individuals to specific pathogens in order to understand why some children get sick during the course of infection while others exposed to the same pathogen do not Casanova was the first to establish that a predisposition to infectious diseases in children can be genetically determined Casanova received his M D from the University of Paris Descartes in 1987 and his Ph D in immunology from the University of Paris Pierre and Marie Curie in 1992 He was an international research scholar with HHMI from 2005 to 2008 and joined the faculty at Rockefeller as professor in 2008 HHMI chose the new investigators after the applicants were narrowed down to 59 semifinalists who were invited to give a brief research talk at the institute s Janelia Farm Research

    Original URL path: http://newswire.rockefeller.edu/2013/05/09/jean-laurent-casanova-appointed-hhmi-investigator/ (2016-02-13)
    Open archived version from archive