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  • intrinsic immunity | Newswire
    defect leaves some children susceptible to a rare and damaging brain infection and have found evidence of an intrinsic immune mechanism in the brain that fights the viral infection in healthy people More Tags brain herpes simplex encephalitis immunity intrinsic immunity Jean Laurent Casanova neuron Shen Ying Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/tag/intrinsic-immunity/ (2016-02-13)
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  • neuron | Newswire
    leaves some children susceptible to a rare and damaging brain infection and have found evidence of an intrinsic immune mechanism in the brain that fights the viral infection in healthy people More Tags brain herpes simplex encephalitis immunity intrinsic immunity Jean Laurent Casanova neuron Shen Ying Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video

    Original URL path: http://newswire.rockefeller.edu/tag/neuron/ (2016-02-13)
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  • Shen-Ying Zhang | Newswire
    defect leaves some children susceptible to a rare and damaging brain infection and have found evidence of an intrinsic immune mechanism in the brain that fights the viral infection in healthy people More Tags brain herpes simplex encephalitis immunity intrinsic immunity Jean Laurent Casanova neuron Shen Ying Zhang St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics

    Original URL path: http://newswire.rockefeller.edu/tag/shen-ying-zhang/ (2016-02-13)
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  • Protein proves vital in immune response to bacteria | Newswire
    no known cause ISG15 proved to be a new genetic link to the disease which has several other genes attributed to it What s interesting here in addition to finding a new genetic mutation that causes susceptibility to mycobacterial disease is that while these children became very very sick from a bacterium that would not harm you or me they had normal reactions to viral infection says Bogunovic They ve seen flu chicken pox and they re fine So it turns out that this gene is essential for immunity against bacteria It could be important in fighting viruses but it s not essential ISG15 is a protein involved in a cascade of protein cell interactions that help drive the immune system to eliminate a pathogen from the body In studies spanning two and a half years Bogunovic and colleagues worked out the protein s function They found it was secreted by granulocytes a type of white blood cell and that it prompted another white blood cell called a natural killer cell to release interferon gamma a protein crucial to fighting mycobacterial infections To test whether this genetic mutation was in fact causing mycobacterial disease among the three children Bogunovic exposed samples of their blood to a tuberculosis vaccine routinely given to children in Europe and elsewhere Using a mild form of the tuberculosis bacterium the vaccine exposes children to the disease and prompts the immune system to fight it off and remember it reducing the chances of getting sick from full blown tuberculosis in the future The patients in this study had low levels of interferon gamma in response to the vaccine indicating their immune systems weren t fighting it When Bogunovic added the ISG15 protein to the blood samples interferon gamma levels shot up This and other tests proved

    Original URL path: http://newswire.rockefeller.edu/2012/08/10/protein-found-to-be-vital-in-immune-response-to-bacteria/ (2016-02-13)
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  • Jean-Laurent Casanova to receive 2012 Milstein Award | Newswire
    lupus The Milstein Award which represents the pinnacle of scientific achievement in interferon and cytokine research is bestowed upon a leading biomedical research scientist who has made outstanding contributions to interferon and cytokine research either in a basic or applied field Many laureates have made seminal advancements that have enabled the successful treatment of disease or have the potential to lead to significant health benefits for humanity Among Casanova s many contributions is the discovery of a new group of genetic defects that predispose otherwise healthy individuals or populations to a single type of infection His discoveries have altered a paradigm that has prevailed in this field for decades These discoveries have shaped the specific working hypothesis that severe infectious diseases of childhood result from collections of rare single gene variations Casanova s work helped to decipher the molecular genetic basis of various pediatric infectious diseases including mycobacterial diseases invasive pneumococcal disease herpes simplex encephalitis and chronic mucocutaneous candidiasis These studies have important clinical implications as they provide a basis for genetic counseling and a rationale for developing new therapeutic approaches based on an understanding of the host component of infectious diseases These studies also have major biological implications as they define or help to define the functions of many of these host defense genes Casanova was an international research scholar with the Howard Hughes Medical Institute from 2005 to 2008 and was appointed professor and head of laboratory at Rockefeller in 2008 He is a member of the European Molecular Biology Organization and the American Society for Clinical Investigation Casanova was the recipient of the Professor Lucien Dautrebande Pathophysiology Foundation Prize from the Belgian Royal Academy of Medicine in 2004 the Richard Lounsbery Award from the French and American Academies of Sciences in 2008 the Oswald Avery Award from

    Original URL path: http://newswire.rockefeller.edu/2012/08/08/jean-laurent-casanova-to-receive-2012-milstein-award/ (2016-02-13)
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  • Jean-Laurent Casanova honored with Belgium’s highest scientific prize | Newswire
    Latour Health Prize which recognizes the practical application of basic research is the most important scientific prize awarded in Belgium Casanova studies the genetics of human predisposition to pediatric infectious diseases particularly mycobacterial diseases invasive pneumococcal diseases and herpes simplex encephalitis He is interested in identifying Mendelian holes in the immune defense of otherwise healthy children who are susceptible to specific infectious diseases work that has profound implications for and has resulted in a paradigm shift in human clinical medicine and fundamental immunology Casanova was the first to establish that a predisposition to infectious diseases in children can actually be genetically determined Casanova received his M D from the University of Paris René Descartes in 1987 and his Ph D in immunology from the University of Paris Pierre and Marie Curie in 1992 after being trained at the Pasteur Institute in Paris and the Ludwig Institute for Cancer Research in Lausanne Following a residency in pediatrics in Paris he completed a clinical fellowship in the pediatric immunology hematology unit of the Necker Medical School in Paris In 1999 he was appointed a professor of pediatrics at Necker where with Laurent Abel he cofounded and codirected the Laboratory of Human Genetics of Infectious Diseases He was appointed professor at Rockefeller in 2008 Casanova was an international research scholar with the Howard Hughes Medical Institute from 2005 to 2008 and is a member of the European Molecular Biology Organization and the American Society for Clinical Investigation Casanova is the recipient of the 2008 Richard Lounsbery Award from the French and American Academies of Sciences and a Professor Lucien Dautrebande Pathophysiology Foundation Prize from the Belgian Royal Academy of Medicine in 2004 Casanova received an honorary doctorate from the University of Zürich in 2009 and he received the 2009 Oswald Avery Award from

    Original URL path: http://newswire.rockefeller.edu/2011/05/05/jean-laurent-casanova-honored-with-belgium%e2%80%99s-highest-scientific-prize/ (2016-02-13)
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  • InBev-Baillet Latour Health Prize | Newswire
    received the 2011 InBev Baillet Latour Health Prize Belgium s most important scientific prize for his pioneering work on the identification of genes that predispose for human infectious disease More Tags InBev Baillet Latour Health Prize Jean Laurent Casanova St Giles Laboratory of Human Genetics of Infectious Diseases Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About

    Original URL path: http://newswire.rockefeller.edu/tag/inbev-baillet-latour-health-prize/ (2016-02-13)
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  • Rockefeller immunologist receives Gates Foundation Grand Challenges grant | Newswire
    a new project aimed at understanding how a collection of genetically diverse errors in immunity leads to susceptibility to tuberculosis in children under 15 years old Although the M tuberculosis bacterium is present in about a third of the world s population only five percent of infected individuals develop clinical tuberculosis The new study will build on a collaboration with clinicians in Turkey Morocco and Iran three countries of distinct genetic background with a fairly high incidence of tuberculosis By looking at specific genes in each of 90 children from those countries Casanova hopes to find specific genetic mutations that may lead to a failure of protective immunity and that may be responsible for tuberculosis predisposition Casanova joined Rockefeller in September 2008 from Hospital Necker for Sick Children in Paris His research is aimed at identifying genetic mutations that predispose individuals to specific pathogens in order to understand why some children get sick during the course of infection while others exposed to the same pathogen do not His work has paved the way for developing treatments that are based on a rational understanding of the human genetics of infectious diseases Globally over 80 000 children die from tuberculosis each year and antibiotics which kill the bacteria also run the risk of establishing drug resistant strains There is an urgent need to develop novel therapeutic approaches to tuberculosis Casanova says We hope that by better understanding the genetic basis of childhood tuberculosis we will illuminate this disease s pathogenesis and lay the foundation for the design of immune restoring treatments The winners of these grants show the bold thinking we need to tackle some of the world s greatest health challenges said Tachi Yamada president of the Gates Foundation s Global Health Program I m excited about their ideas and look

    Original URL path: http://newswire.rockefeller.edu/2010/05/12/rockefeller-immunologist-receives-gates-foundation-grand-challenges-grant/ (2016-02-13)
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