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  • differentiation | Newswire
    to a protein the cells began dividing prematurely Meanwhile when the same was done to their progeny cells the fate of these cells shifted More Tags BMP signaling differentiation Elaine Fuchs hair follicle Laboratory of Mammalian Cell Biology and Development Maria Genander Stem Cells Development Regeneration transit amplifying cells August 4 2014 Science News An embryonic cell s fate is sealed by the speed of a signal Early in development

    Original URL path: http://newswire.rockefeller.edu/tag/differentiation/ (2016-02-13)
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  • Memorial Sloan Kettering Cancer Center | Newswire
    decision to pick a fate or renew themselves In experiments exposure to a key metabolite called alpha ketoglutarate enhanced the renewal of mouse embryonic stem cells More Tags alpha ketoglutarate Bryce Carey chromatin Craig Thompson David Allis differentiation epigenetics Lydia Finley Memorial Sloan Kettering Cancer Center metabolism methylation stem cells Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011

    Original URL path: http://newswire.rockefeller.edu/tag/memorial-sloan-kettering-cancer-center/ (2016-02-13)
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  • methylation | Newswire
    pick a fate or renew themselves In experiments exposure to a key metabolite called alpha ketoglutarate enhanced the renewal of mouse embryonic stem cells More Tags alpha ketoglutarate Bryce Carey chromatin Craig Thompson David Allis differentiation epigenetics Lydia Finley Memorial Sloan Kettering Cancer Center metabolism methylation stem cells Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About

    Original URL path: http://newswire.rockefeller.edu/tag/methylation/ (2016-02-13)
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  • C. David Allis wins the 2015 Breakthrough Prize in Life Sciences | Newswire
    which also featured the actors Kate Beckinsale Benedict Cumberbatch Cameron Diaz Jon Hamm and Eddie Redmayne as presenters Through his work on histone modifications David has opened new doors of scientific understanding for colleagues around the world interested in penetrating the complexities of gene expression says Marc Tessier Lavigne Rockefeller president Carson Family Professor and head of the Laboratory of Brain Development and Repair The Breakthrough Prize is a wonderful confirmation of the impact of his truly pathbreaking research The judges recognized Allis for the discovery of covalent modifications of histone proteins and their critical roles in the regulation of gene expression and chromatin organization advancing the understanding of diseases ranging from birth defects to cancer Histones are DNA packaging proteins one component of chromatin the material of which chromosomes are composed Over the last decade Allis and others have provided evidence that suggests that patterns or combinations of chemical modifications to histones represent a layer of gene regulation that takes place away from the DNA an epigenetic layer of regulation Epigenetic errors have been associated with cancer and other diseases and scientists growing understanding of fundamental mechanisms involved holds great promise for entirely new treatment approaches Histone modifications have also been found to play an important role in cell reprogramming and are expected to contribute to the field of regenerative medicine Tracking down answers to these fundamental questions concerning gene regulation has been deeply satisfying More recently too we ve seen that some of our findings are leading to new treatment approaches for difficult diseases says Allis It is an amazing honor for this work to be recognized by such an extraordinary prize and it only increases my gratitude for the opportunity I ve had to pursue a career in science Allis received his Ph D in 1978 from

    Original URL path: http://newswire.rockefeller.edu/2014/11/10/c-david-allis-wins-the-2015-breakthrough-prize-in-life-sciences/ (2016-02-13)
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  • In the News – Forbes – Allis | Newswire
    science Called epigenetics it is the study of a phenomenon that 20th century biology said shouldn t exist changes in molecules that are outside the DNA but can nevertheless be passed from cell to cell or even from one generation to the next Tags Breakthrough Prize C David Allis epigenetics newswire rockefeller edu 3D deep imaging advance likely to drive new biological insights C David Allis wins the 2015 Breakthrough

    Original URL path: http://newswire.rockefeller.edu/2014/11/09/in-the-news-forbes-allis/ (2016-02-13)
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  • Researchers create the first model of the DNA ‘replication fork’ | Newswire
    Biology focus on eukaryotic cells All multicellular life including humans is eukaryotic Single celled prokaryotes evolved a different method for replicating their DNA In order to study the replication fork O Donnell and his laboratory needed to recreate the process in a simple model In a test tube they brought together a set of DNA building blocks known as nucleotides a double stranded molecule of DNA and the enzymes essential to the process These enzymes came from the yeast fungus which is a eukaryote According to O Donnell the team s technique may allow researchers to reconstruct biochemical events that were until now difficult or impossible to study in detail For example scientists know some inheritable information known as epigenetic information is not encoded in the DNA but instead lies in modifications to proteins associated with the DNA Yet exactly how this information is passed on remains a mystery Scientists also don t know what happens when the replication fork encounters an area of damaged DNA as it travels down the length of the molecule These processes have direct implications for the study of diseases such as cancer that can arise from DNA damage or problems with epigenetic inheritance Scientists already know the replication fork is assembled as a complex of numerous proteins that unwinds and separates the DNA into two individual strands The emerging replication fork looks much like a zipper opening with a protein complex in the role of a zipper slider and the two strands of the separating DNA molecule appearing like the two rows of teeth of the open zipper Each side of the zipper becomes the template for a daughter strand but the mechanics differ depending on the side The researchers in O Donnell s lab took a close look at this essential asymmetry which

    Original URL path: http://newswire.rockefeller.edu/2014/07/23/researchers-create-the-first-model-of-the-dna-replication-fork/ (2016-02-13)
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  • replication fork | Newswire
    new tool promises to allow scientists to explore the as yet unknown details of how cells unzip the double stranded DNA molecule and replicate it a process crucial to life More Tags DNA replication epigenetics Michael O Donnell replication fork Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The Rockefeller University RU

    Original URL path: http://newswire.rockefeller.edu/tag/replication-fork/ (2016-02-13)
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  • David Allis, pioneer in epigenetics, to receive prestigious Japan Prize | Newswire
    that act as spools around which a cell s DNA is coiled Allis s discovery that chemical tags bind to specific sections of histone proteins in order to activate or silence nearby genes has ignited the field of epigenetics a relatively new area of study which explores the inheritance of physical changes that cannot be traced back to mutations in the DNA sequence Over the last decade Allis and his colleagues have provided evidence that suggests that patterns or combinations of these histone modifications represent another layer of gene regulation that takes place away from DNA itself Indeed recent studies have identified epigenetic changes as a factor in the development of some types of cancer providing the basis for the development of new classes of anti cancer drugs Histone modifications have also been found to play an important role in cell reprogramming and are expected to contribute to the field of regenerative medicine David is an exceptional scientist and mentor whose studies have added an entirely new dimension to our understanding of cellular regulation and the relationship between genes and disease says Marc Tessier Lavigne Rockefeller s president It is enormously gratifying to see him honored with this prestigious international award The Japan Foundation awards the Japan Prize every year to scientists and researchers in two categories who regardless of nationality have made substantial contributions to their fields as well as to peace and prosperity of mankind Since its inception in 1985 the Japan Prize has been awarded to 81 people from 13 countries Alongside Allis Yasuharu Suematsu of the Tokyo Institute of Technology was awarded this year s prize in electronics information and communication for his research on semiconductor lasers in optical fiber communication Allis is the Joy and Jack Fishman Professor and head of Laboratory of Chromatin Biology

    Original URL path: http://newswire.rockefeller.edu/2014/01/28/david-allis-pioneer-in-epigenetics-to-receive-prestigious-japan-prize/ (2016-02-13)
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