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  • Stem Cells Development Regeneration | Newswire
    to respond to a protein the cells began dividing prematurely Meanwhile when the same was done to their progeny cells the fate of these cells shifted More Tags BMP signaling differentiation Elaine Fuchs hair follicle Laboratory of Mammalian Cell Biology and Development Maria Genander Stem Cells Development Regeneration transit amplifying cells Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012

    Original URL path: http://newswire.rockefeller.edu/tag/stem-cells-development-regeneration/ (2016-02-13)
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  • transit amplifying cells | Newswire
    Elaine Fuchs hair follicle Laboratory of Mammalian Cell Biology and Development Maria Genander Stem Cells Development Regeneration transit amplifying cells May 8 2014 Science News Stem cell progeny tell their parents when to turn on During an infection the immune system selects B cells that produce antibodies with a high affinity for the pathogen New research helps explain the details of how these cells are selected and amplified More Tags

    Original URL path: http://newswire.rockefeller.edu/tag/transit-amplifying-cells/ (2016-02-13)
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  • Daniel Schramek awarded Regeneron Prize for Creative Innovation by a Postdoctoral Fellow | Newswire
    nominated by the deans of their institutions to submit a dream project in biomedical research that they would tackle given today s technological limitations but with limitless resources Schramek proposed using sequence based personalized medicine to treat the most devastating features of cancer problems such as metastasis drug resistance and dormancy in patient specific ways Schramek who received his Ph D in genetics from the University of Vienna and the Austrian Academy of Sciences joined Rockefeller in 2011 as an Emerald Foundation Young Investigator Schramek is currently studying MYH9 a tumor suppressor gene that codes for a motor protein important in cell structure and migration In a recent paper in Science Schramek and his colleagues describe how MYH9 is mutated in many cancers and has implications especially for head and neck cancers Regeneron is a biopharmaceutical company based in Tarrytown New York that aims to develop medicines for diseases of high unmet medical need including eye diseases colorectal cancer and a rare inflammatory condition The prize is designed to recognize excellence in biomedical science and to foster talented early career scientists Each institution may nominate two graduate students and two postdoctoral fellows Ten finalists selected by Regeneron scientists are invited

    Original URL path: http://newswire.rockefeller.edu/2014/06/02/postdoc-daniel-schramek-awarded-regeneron-prize-for-dream-biomedical-project/ (2016-02-13)
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  • Daniel Schramek | Newswire
    being recognized for his proposal of a project that used sequence based personalized medicine to treat the most devastating features of cancer The award comes with a 50 000 prize and a 5 000 donation to support seminars at Rockefeller More Tags cancer Daniel Schramek Elaine Fuchs MYH9 Regeneron Regeneron Prize for Creative Innovation Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015

    Original URL path: http://newswire.rockefeller.edu/tag/daniel-schramek/ (2016-02-13)
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  • MYH9 | Newswire
    recognized for his proposal of a project that used sequence based personalized medicine to treat the most devastating features of cancer The award comes with a 50 000 prize and a 5 000 donation to support seminars at Rockefeller More Tags cancer Daniel Schramek Elaine Fuchs MYH9 Regeneron Regeneron Prize for Creative Innovation Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014

    Original URL path: http://newswire.rockefeller.edu/tag/myh9/ (2016-02-13)
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  • Regeneron Prize for Creative Innovation | Newswire
    is being recognized for his proposal of a project that used sequence based personalized medicine to treat the most devastating features of cancer The award comes with a 50 000 prize and a 5 000 donation to support seminars at Rockefeller More Tags cancer Daniel Schramek Elaine Fuchs MYH9 Regeneron Regeneron Prize for Creative Innovation Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive

    Original URL path: http://newswire.rockefeller.edu/tag/regeneron-prize-for-creative-innovation/ (2016-02-13)
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  • Stem cell progeny tell their parents when to turn on | Newswire
    growth and repair Many tissues have two populations of stem cells one that divides rarely known as the quiescent stem cells and another that is more prone to proliferate known as primed stem cells Regardless of their proliferation frequency most stem cells in humans do not directly produce differentiated progeny cells instead they give rise to an intermediate proliferating population the TACs The hair follicle the tiny organ that produces a hair forms a narrow cavity down into the skin It cycles between rounds of growth destruction and rest When entering the growth phase the primed stem cell population is always the first to divide and generates the TACs clustered lower down in the hair follicle Primed stem cell proliferation sets the stage for the next round of hair growth a process which ensures hairs are replaced as they are lost over time Proliferating TACs produce the hair shaft as well as all the cells surrounding the hair underneath the skin which make up the follicle itself At the outset Hsu and Fuchs suspected a role for both the TACs and for Sonic Hedgehog in hair regeneration We noticed that the primed stem cell population gets activated early and makes the TACs while the quiescent stem cell population only becomes activated once TACs are generated This correlation prompted us to look for a signal that is made by the TACs Sonic Hedgehog is that signal as we went on to demonstrate explained Fuchs In experiments described this week in Cell Hsu disabled TACs ability to produce the Sonic Hedgehog protein by knocking out the gene responsible in the hair follicles of adult mice As a result the proliferation of hair follicle stem cells and their TACs are both compromised They further showed that it is the quiescent stem cell population

    Original URL path: http://newswire.rockefeller.edu/2014/05/08/stem-cell-progeny-tell-their-parents-when-to-turn-on/ (2016-02-13)
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  • sonic hedgehog | Newswire
    immune system selects B cells that produce antibodies with a high affinity for the pathogen New research helps explain the details of how these cells are selected and amplified More Tags Elaine Fuchs sonic hedgehog stem cells transit amplifying cells Ya Chieh Hsu Search for Categories Science News Awards and Honors Campus News Grants Gifts Topics Video Archive 2015 2014 2013 2012 2011 more About Contact Follow rockefelleruniv Like The

    Original URL path: http://newswire.rockefeller.edu/tag/sonic-hedgehog/ (2016-02-13)
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