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  • Ebola Outbreaks
    Ebola Outbreaks Ebola Cote d Ivoire Ebola Reston Ebola Sudan Ebola Zaire 1999 Marburg Outbreak 1999 Tara Waterman

    Original URL path: http://virus.stanford.edu/filo/outbreaks.html (2016-02-13)
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  • Ebola Electron Micrographs
    Micrographs First Picture of Ebola Marburg Between Two Human Liver Cells 1977 Ebola Zaire Micrograph Taken By Dr W Slenczka Ebola Reston Electron micrographs and immunohistochemistry images of the pathogenesis

    Original URL path: http://virus.stanford.edu/filo/em.html (2016-02-13)
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  • Ebola Human Diseases
    inside and that is then followed by severe bleeding which can come from external orifices such as the nose gums the rectum and also from the uterus But there is also severe bleeding into the gastrointestinal organs as well with severe damage to the kidneys liver and also the spleen From an Outbreak interview David L Heymann MD Director of Emerging Viral and Bacterial Diseases Surveillance and Control World Health Organization The symptoms which occur in Ebola are very similar to those which occur in may other diseases in tropical Africa Fever up to 40 degrees centigrade extreme fatigue muscle and joint pain headache especially frontal headache hiccups and hiccups in this case are a very bad sign They are associated with a very severe prognosis probably because of irritation to the diaphragm ocular injection and in very light skinned persons a macular rash After the sixth day on days seven and eight there is actually a clinical improvement in many cases and a decrease in fatigue and many persons feel extremely well during this period For many this is only the beginning of a cure and as you know there is about a 30 survival rate in this disease For those unfortunate ones who don t survive on day nine onwards they begin with hemorrhagic signs which you know well from having seen films from the outbreak in Zaire Bleeding from the orifices and eventually death So these are the signs and symptoms of Ebola which show that this disease in its early phase is very difficult to distinguish from other diseases in tropical Africa From his EIINet Seminar 2 April 1996 Signs and Symptoms of Ebola Hemorrhagic Fever Fever 90 100 2 Headache 40 90 2 Chills 3 Myalgia arthralgia 40 80 2 Malaise 75 85 2 Pharyngitis

    Original URL path: http://virus.stanford.edu/filo/humandiseases.html (2016-02-13)
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  • Ebola Tissue Tropism and Pathogenesis
    that Ebola attacks cells important to the function of lymphatic tissues It can be found in fibroblastic reticular cells FRC among the loose connective tissue under the skin and in the FRC conduit FRCC in lymph nodes This allows the virus to rapidly enter the blood and leads to disruption of lymphocyte homing at high endothelial venules HEV For more information about the relationship of ebola pathogenesis to lymphocyte homing in lymph nodes please see Role of the FRCC in Lymphocyte Homing Ebola virus seems to be most active in infecting fibroblasts of any type especially fibroblastic reticular cells The next most frequent cell types are mononuclear phagocytes with dendritic cells more affected than monocytes or macrophages Endothelial cells become infected after the the connective tissue surrounding them is fully involved Then almost as a final insult epithelial cells of any type are infected In general epithelial cells become infected only if they contact other cells that amplify the virus such as fibroblastic reticular cells FRC and mononuclear cells This would be true for skin appendages like hair follicles and sweat glands because they are heavily vascularized and have a lot of FRC networks associated with them Liver cells and

    Original URL path: http://virus.stanford.edu/filo/trop.html (2016-02-13)
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  • Ebola Immune Response and Host Defenses
    is known about the host immune response to infection Antibodies that are produced primarily attack the surface glycoproteins of the virus There is very little or no cross reactivity and cross immunity amongst the filoviruses Researchers are not even sure

    Original URL path: http://virus.stanford.edu/filo/immune.html (2016-02-13)
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  • Ebola Reservoir/Natural Host
    of much effort dedication time and treasure as of June 1999 the natural host reservoir of Ebola has yet to be determined There are several promising theories but the natural host reservoir has yet to be conclusively identified The promising

    Original URL path: http://virus.stanford.edu/filo/reservoir.html (2016-02-13)
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  • Ebola Hemorrhagic Fever Management and Therapy
    survivors 2 A potential promising vaccine that offered considerable protection against Ebola to guinea pigs 3 In mice used as a model for Ebola infections a series of nucleoside analogue inhibitors of S adenosylhomocysteine hydrolase provided protection against Ebola Zaire when administered within 2 days of Ebola Zaire infection References Kudoyarova Zubavichene NM et al Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections Journal

    Original URL path: http://virus.stanford.edu/filo/management.html (2016-02-13)
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  • Ebola Prevention
    construction of a BSL4 lab were to begin the authorities would be alerted by people purchasing the BSL4 lab equipment Ebola is stable and remains infective at room temperature 20 C but it is mostly destroyed at 60 C Its infectivity is also terminated by gamma and ultraviolet radiation lipid solvents dissolves the outer lipid membrane ß propiolactone and commercial hypochlorite bleach and phenolic disinfectants Nonhuman Primate Quarantine Regulations After

    Original URL path: http://virus.stanford.edu/filo/prevention.html (2016-02-13)
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