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  • Chang Lab | Perfectionism and Optimism-Pessimism
    active labs include the Optimism Pessimism Lab and the Perfectionism Lab In addition to these labs additional labs have come into operation from time to time including the Social Problem Solving Lab American Dream Lab and Violence Ideation Lab Also the development of new labs is always under consideration If you are interested in learning more about each specific lab please view our Lab Descriptions If you have questions or

    Original URL path: https://sites.lsa.umich.edu/chang-lab/ (2016-04-29)
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  • Chapman Lab | Molecular, Cellular and Developmental Biology
    developed a library of peptidomimetic compounds that can be potent amyloid modifiers We are using these 2 pyridone molecules as tools to better understand amyloid formation and also as inhibitors of amyloid dependent bacterial processes such as biofilm formation High resolution EM analysis of purified CsgG his protein reveals donut shaped structures approximately 15 nM in diameter Negative stain electron microscopy shows that curli are 4 7 nm wide fibers of varying lengths Bacterial amyloid fibers formed by the polymerization of the CsgA protein from E coli Freeze fracture deep etch electron micrograph showing colonies of curliated E coli after 48 hours of growth Curli fibers surround and connect individual bacteria into small groups Curli are extracellular organelles produced by Escherichia coli and certain Salmonella species These fibers are structurally and biochemically identical to eukaryotic amyloid fibers which underlie diverse mammalian ailments including Alzheimer s disease AD systemic amyloidosis bovine spongiform encephalopathy mad cow disease and Creutzfeldt Jacob disease among others The Chapman lab uses the curli system to study the fundamental principles of amyloid formation We continue to dissect the biogenesis of curli fibers as well as the consequences of curli amyloid formation on the biology of microbial communities

    Original URL path: http://sites.lsa.umich.edu/chapman-lab/ (2016-04-29)
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  • Collins Lab | Molecular Cellular & Developmental Biology
    of signaling within axons which connect neurons to distant parts of the brain and body How do signals traverse the long distance in axons from the synapse to the nucleus And how do neurons interpret the signals in order to change specific aspects of their axonal or dendritic processes An important kind of information that neurons respond to is that of axonal damage How do neurons detect and respond to damage at a distant site of injury Many neurons have the capacity to re grow regenerate axons after injury What is the cellular machinery that promotes this response To address these questions we combine approaches of live imaging molecular genetics biochemistry and cell biology using Drosophila as a model organism We have recently developed assays for axonal injury regeneration and degeneration in Drosophila larvae These assays take advantage of the simple neuroanatomy powerful genetics and amenability to live imaging of Drosophila to dissect the cellular mechanisms of injury response and regeneration in neurons Lab News September 2014 Jiaxing gives a talk at the Cold Spring Harbor Axon Meeting September 2014 Undergrad Alum Ruohan Wang begins PhD work at CalTech September 2014 new undergraduate Cary Huang joins the lab August 2014

    Original URL path: http://sites.lsa.umich.edu/collins-lab/ (2016-04-29)
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  • Contexts of Academic & Social Adjustment | Dr. Deborah Rivas-Drake, University of Michigan
    of their ethnic racial iden tity how they learn about it at home with their families and at school with their friends as well as how it changes over time We also examine how ethnic racial identity is linked to academic and social outcomes across adolescence and young adulthood Socialization We examine how families teach their adolescents about race and ethnicity and how such teachings can support positive youth development

    Original URL path: http://sites.lsa.umich.edu/casalab/ (2016-04-29)
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  • The Cundiff Laboratory | The Interaction of Short-Pulsed Lasers with Matter
    Pathfinder Fog Island Synchronized Swimming in a Two Dimensional Electron Gas Adventures in Coupling From the response of the material to normal laser light left the effects due to a Schrödinger Cat state can be calculated right Credit The Cundiff group and Brad Baxley JILA Highlighted Publications G Moody Akimov I A Li H Singh R Yakovlev D R Karczewski G Wiater M Wojtowicz T Bayer M and Cundiff S T Coherent Coupling of Excitons and Trions in a Photoexcited CdTe CdMgTe Quantum Well Phys Rev Lett vol 112 p 097401 2014 G Nardin Moody G Singh R Autry T M Li H Morier Genoud F and Cundiff S T Coherent Excitonic Coupling in an Asymmetric Double InGaAs Quantum Well Arises from Many Body Effects Phys Rev Lett vol 112 p 046402 2014 A E Hunter Li H Cundiff S T Mootz M Kira M and Koch S W Quantum Droplets of Electrons and Holes Nature vol 506 pp 471 475 2014 H Li Bristow A D Siemens M E Moody G and Cundiff S T Unraveling quantum pathways using optical 3D Fourier transform spectroscopy Nature Communications vol 4 p 1390 2013 G Moody Singh R Li H Akimov I

    Original URL path: https://sites.lsa.umich.edu/cundiff-lab/ (2016-04-29)
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  • Dus Lab | Faculty, Lab, and Research Template Site
    to the presence and absence of sugar Neural circuits in the brain regulate feeding behavior through the secretion of hormones neuropeptides and the activation of neural pathways to peripheral organs Our goal is to understand the mechanisms neurons use to sense and respond to variations in nutrient levels to regulate feeding behavior and ensure energy balance MOLECULAR CELLULAR DEVELOPMENTAL BIOLOGY CONTACT Primary Investigator Monica Dus Ph D Assistant Professor Department

    Original URL path: https://sites.lsa.umich.edu/dus-lab/ (2016-04-29)
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  • Fierke Research Group | Faculty, Lab, and Research Template Site
    Alumni Programs Publications Home WELCOME TO THE FIERKE RESEARCH GROUP WEBPAGE Our research is focused on understanding the chemical mechanism and structure function relationships of important biological molecules as well as studying the biochemistry of transitional metal ions such as zinc Current areas of active investigation include zinc enzymes ribozymes cellular imaging biosensors and protein engineering Our lab is located on the 4th floor of the Dow Chemistry building over

    Original URL path: https://sites.lsa.umich.edu/fierkelab/ (2016-04-29)
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  • Gender and Personality in Context Lab | Faculty, Lab, and Research Template Site
    participation by faculty and students with interests in personality and gender in context We are broadly inclusive and use our meetings usually alternate weeks for informal discussion of disciplinary issues professional socialization career development journal reviewing etc and articles as well as more formal presentations usually for practice We try to maintain an informal collegial atmosphere and enjoy collaborating with other UM faculty and students and with visitors with shared

    Original URL path: http://sites.lsa.umich.edu/abigailstewart-lab/ (2016-04-29)
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