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  • CTP Fellows | Fellows Program | Cal Turner Program | Vanderbilt University
    School Megan Black Arfraja McLeod Naomi Yoder James Alexander Peabody College of Education Emmanuel Legrair Leanne Lytle Preston Magouirk Payton Richardson Law School Samiyyah Ali Lawrence Crane Moscowitz Matthew Gornick Megan McLean Owen Graduate School of Management Sarah Berhalter Geoff Blair Jacob Hill School of Medicine Brendan Hayes Jasia Mahdi Charles Rodriguez Feo School of Nursing Laura Hollis Rishi Mistry Raymond Romano 2013 2014 Fellows Divinity School Nicole Maleveaux Asher Kolieboi Steven Dueck Peabody College of Education Jeff Jorg Erika Lyn Larson Betsega Bekele Law School John Elrod Kendra Key Owen Graduate School of Management Rachel Taplinger Hemant Nelaparthi School of Medicine Marta Perez Grace Ho School of Nursing James Kelly Speck Rob Nash Kathryn Fischer 2011 2012 Fellows Divinity School Allyn L Steele Zach Carmichael Emily Rowell Peabody College of Education Shaka Dickerson Hannah Grace Rowland Karishma Merchant Elizabeth A Ehly School of Engineering Todd Peter Lagus Law School Ana Valisa Berber Thayer Daniel A Horwitz Cong Denny Nie Courtnee Reid Owen Graduate School of Management Samuel J Frank Melissa A Skinner Daniel J Angius Mario Avila School of Medicine Eryka Gayle William Sullivan Rachel Ruiz School of Nursing Meghan E Rowland Joseph Ojibway Asa T Briggs Richard Clews 2010 2011 Fellows College of Arts and Science Logan Van Meter Divinity School Elizabeth Coyle James Squibb Lindsey Krinks Kelley Frances Fenelon Peabody College of Education Christopher Keyes Courtney Williams Katie Knies Daniel Robbins Kristin Ware Law School Jack Arnold Timothy Lessler Tonya Ogden Geraldine Young Owen Graduate School of Management Israel Ovalle Amrita Dutta Gupta Heather Graham School of Medicine Matt Kynes Shane Magee School of Nursing Elizabeth Morse Courtney Massaro 2009 2010 Fellows College of Arts and Science Bakh Mirkasimov Divinity School Elizabeth Williams Chris McCain Jen Simon Cameron Barr Peabody College of Education Amanda Taylor Mikel Cole

    Original URL path: http://www.vanderbilt.edu/ctp/fellows/past.php (2016-02-16)
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  • Community Partners | Cal Turner Program | Vanderbilt University
    adaptive leadership suggests that there are basically two kinds of problems technical problems and adaptive challenges Sharon Daloz Parks explains Technical problems even though they may be complex can be solved with knowledge and procedures already in hand For example replacing a faulty heart value during cardiac surgery is a known solution that can be implemented by current know how In contrast adaptive challenges require new learning innovation and new patterns of behavior In this view leadership is the activity of mobilizing people to address adaptive challenges those challenges that cannot be resolved by expert knowledge and routine management alone Adaptive challenges often appear as swamp issues tangled complex problems composed of multiple systems that resist technical analysis and thus stand in contrast to the high hard ground issues that are easier to address but where less is at stake for the organization or for society They ask for more than changes in routine or mere preference They call for changes of heart and mind the transformation of long standing habits and deeply held assumptions and values Leadership Can Be Taught 10 Our hope is that the CTP Fellows can help Community Partners tackle adaptive challenges though they may work on technical problems as well Guiding the Fellows Project Each Fellows Team will meet at least twice a semester with their Community Partner to learn what it means to serve the Nashville area as a non profit to spend time with the clients served and to assess identify and think through a challenge the Community Partner faces In this way the Fellows serve as students of and consultants to their partners The goal is for the Fellows Team to provide 30 hours of service total during the academic year to their Community Partner which may include direct service event attendance

    Original URL path: http://www.vanderbilt.edu/ctp/communitypartners.php (2016-02-16)
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  • Collaborations | Cal Turner Program | Vanderbilt University
    Education Pilot Project Woman to Woman Home Collaborations Collaborations The Cal Turner Program collaborates with many organizations at Vanderbilt within Nashville and across the nation Some of our partnerships are listed below Art Advocacy Action in partnership with Vanderbilt Divinity School Inter Professional Education IPE Student Pilot Project in partnership with the Vanderbilt Meharry Alliance Woman to Woman in partnership with the Scarritt Bennett Center Partner Organizations Association for Practical

    Original URL path: http://www.vanderbilt.edu/ctp/collaborations.php (2016-02-16)
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  • Vanderbilt Institute of Chemical Biology
    expressed almost exclusively in dendrites and spines of neurons in hippocampal area CA2 Knock out of the RGS14 gene protein results in mice that learn faster and remember better Loss of RGS14 also results in nascent long term potentiation LTP and synaptic plasticity in CA2 neurons where it is otherwise absent Synaptic plasticity and LTP is regulated by both Ca Calmodulin CaM CaMKII and ERK signaling At the cellular level RGS14 binds inactive Gai GDP which anchors it at the plasma membrane RGS14 also binds active H Ras GTP and binding of H Ras inhibits stimulated ERK signaling RGS14 also binds Ca activated Calmodulin Ca CaM and is phosphorylated by CaMKII The Gai1 RGS14 signaling complex is regulated by Gi linked GPCRs A model if proposed whereby RGS14 integrates G protein H Ras ERK and Ca CaM signaling pathways to regulate synaptic signaling plasticity and hippocampal learning and memory John Porco Boston University Recent Studies Towards The Synthesis of Tetrahydroxanthone Natural Products Wednesday November 18 2015 12 15 P M 1 15 P M 1220 MRB III Key Lecture Points A concise approach to additional tetrahydroxanthone natural products employing vinylogous addition of siloxyfurans to benzopyryliums derived from chromones and a late stage Dieckmann cyclization has also developed 1 The methodology led to development of efficient syntheses of the antitumor agents secalonic acids A and D 2 as well as a seven step atropselective total synthesis of the dimeric tetrahydroxanthone antibioticrugulotrosin A 3 1 Vinylogous Addition of Siloxyfurans to Benzopyryliums A Concise Approach to the Tetrahydroxanthone Natural Products Qin T Johnson R P and Porco J A Jr J Am Chem Soc 2011 133 1714 1717 2 Total Syntheses of Secalonic Acids A and D Qin T Porco J A Jr Angew Chem Int Ed Engl 2014 53 3107 3110 3 Atropselective Syntheses of and Rugulotrosin A Utilizing Point to Axial Chirality Transfer Qin T Skraba Joiner S L Khalil Z G Johnson R P Capon R J Porco J A Jr Nat Chem 2015 7 234 40 Richard DiMarchi Indiana University Peptide Based Therapeutics From Hormones to Polypharmacy Wednesday December 2 2015 12 15 P M 1 15 P M 1220 MRB III Key Lecture Points Evolution of macromolecule drug synthesis Recruitment of glucagon agonism to treat metabolic diseases Overlapping but unique properties of GIP GLP Preparation of triple agonists and application of lipidation of a medicinal tool Molecular basis for mixed incretin agonism antagonism Mark Brown Cleveland Clinic Gut Microbial Metabolites as Metaorganismal Hormones Regulating Host Energy Metabolism Wednesday December 9 2015 12 15 P M 1 15 P M 1220 MRB III Key Lecture Points Resident microbial communities and host collectively create a metaorganism that promotes metabolism of nutrients that influence susceptibility for the development of CVD Intestinal microbiota dependent metabolism of phosphatidylcholine and L carnitine produces trimethylamine TMA which is further metabolized by the host enzyme Flavin Monooxygenase 3 FMO3 to the proatherogenic compound trimethylamine N oxide TMAO Both TMA and TMAO exhibit properties that are hormone

    Original URL path: http://www.vanderbilt.edu/vicb/events_talkingpoints.html (2016-02-16)
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  • Vanderbilt Institute of Chemical Biology
    funded Integrative Training in Therapeutic Discovery and Chemical Biology Interface Training Grants have supported numerous graduate students and postdoctoral fellows in chemical biology while the NSF sponsored Research Experiences for Undergraduates program brings undergraduate students to campus each summer to work in VICB member laboratories The annual Research Symposium planned and conducted by students provides a forum for the presentation of their latest research and the Chemical Biology Association of Students provides an opportunity to socialize Students interested in formalizing their training may complete the Chemical Biology Certificate Program The VICB in the forefront In the 10 years since its inception the VICB has had a major impact catapulting Vanderbilt to the forefront of chemical biology and drug discovery nationally and internationally It provided the incubator from which Jeff Conn created his highly productive Vanderbilt Center for Neuroscience Drug Discovery It provides ongoing support for Steve Fesik s Cancer Drug Discovery Program Numerous additional drug and molecular probe discovery efforts are thriving on the Vanderbilt campus Included are Alex Brown s collaboration with Craig Lindsley to identify isoform selective inhibitors of phospholipase D Erik Skaar s work to identify new antibiotics to combat drug resistant bacterial infections Larry Marnett s collaboration with Sachin Patel leading to the discovery of substrate selective COX 2 inhibitors that act as anti anxiety agents Charles Hong s discovery of modulators of bone morphogenic protein signaling Larry Zweibel s work on allosteric modulators of olfactory signaling in mosquitoes Ethan Lee s research into the mechanism of action of novel inhibitors of Wnt pathway signaling Jerod Denton s and David Weaver s discovery of novel inhibitors of potassium channel function David Wright s work with Rick Haselton to develop low resource methods to improve malaria diagnosis Charles Manning s discovery of PET imaging agents to identify apoptotic cells in vivo Roger Cone s work to discover modulators of melanocortin receptor signaling These promising discoveries will impact basic science research in a wide range of diseases including cancer obesity diabetes epilepsy malaria bacterial infection and neuropsychiatric diseases Many of the molecular probes already discovered also provide lead molecules for ultimate translation to the clinic The VICB provides a vibrant interdisciplinary environment that fosters new discovery and research innovation at Vanderbilt It will be critical to the future exploration of new dimensions for successful multi investigator initiatives and the ongoing integration of chemical biology education and research into disease focused programs across the Vanderbilt campus Going forward under the leadership of Director Larry Marnett and Associate Directors Eric Skaar Gary Sulikowski Brian Bachmann Alex Brown and Michelle Sulikowski the VICB remains committed to its mission of harnessing the power of chemistry to improve human health Executive Committee Brian Bachmann Chemistry Alex Brown Pharmacology Lawrence Marnett Director Biochemistry Eric Skaar Microbiology Immunology Gary Sulikowski Chemistry Michelle Sulikowski Chemistry CONTACTS Anne B Lara Manager Carol Rouzer Communications Officer Stephen Doster Editor Amanda Renick Education Specialist Operations Committee Rob Carnahan Cancer Biology Charles Hong Jeffrey Johnston Drug Discovery Pharmacology Jens Meiler

    Original URL path: http://www.vanderbilt.edu/vicb/about.html (2016-02-16)
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  • Vanderbilt Institute of Chemical Biology
    pursue your own interests We Have a Great Website You can learn all you need to know about the VICB at our website Take some time to explore our site for graduate student training opportunities and areas of research Vanderbilt Graduate School Online Application Apply for free View the Electronic Application for Chemistry Admissions View all of our Graduate Admissions Programs Contact the VICB For additional information contact the VICB office at vicb vanderbilt edu 615 322 0907 Financial Support Graduate study in Chemical Biology is funded through multiple sources including departmental research or teaching assistantships university fellowships and extra institutional fellowships In addition students in Chemical Biology may apply for support from the specialized Chemistry Biology Interface Training Program Graduate Student Training Opportunities Graduate students in VICB laboratories benefit from the exceptional level of collaboration that naturally flows from the multidisciplinary research approach Students who are interested in Chemical Biology should first learn about the four admission programs through which they may apply for graduate study at Vanderbilt all of which provide access to VICB member labs VICB members represent 18 different departments in Vanderbilt s College of Arts and Sciences and School of Medicine Thus their research interests are diverse Prospective students should explore the VICB research section to search for VICB investigators who are pursuing research of interest to them Admission programs Chemistry Department Graduate Program College of Arts and Science This multidisciplinary Ph D program trains chemists in a number of areas including Chemical Biology go Quantitative Chemical Biology Graduate Program College of Arts and Science and the School of Medicine A program that allows students who have earned undergraduate or masters degrees in the quantitative sciences e g chemistry computer science engineering mathematics or physics to pursue graduate studies at the interface of these disciplines with the biological sciences go Interdisciplinary Graduate Program School of Medicine Individuals pursuing a Ph D in the basic biomedical or biological science departments at Vanderbilt University join participating departments through the Interdisciplinary Graduate Program in the Biomedical Sciences IGP go Medical Scientist Training Program School of Medicine The program provides students with an integrated curriculum that features a strong core education in medicine and intensive training in scientific inquiry Successful completion of the program leads to both the M D and Ph D degrees The Vanderbilt MSTP builds on the existing strengths of Vanderbilt University to meet national needs for well trained basic and clinical biomedical investigators go Other programs Chemistry Biology Interface Training Program The Chemistry Biology Interface CBI Training Program at Vanderbilt University is an NIH sponsored training program that supports graduate students studying at the interface of chemistry and biology go The Certificate Program in Chemical Biology This is a unique program which provides an exciting research and learning environment for students in the basic sciences who are conducting research at the interface of chemistry and biology go Postdoctoral Training The 70 members of the VICB span 18 different departments in the College of Arts and

    Original URL path: http://www.vanderbilt.edu/vicb/training.html (2016-02-16)
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  • Vanderbilt Institute of Chemical Biology
    1 15 P M 1220 MRB III View Key Lecture Points Priscilla Yang Harvard Host Pathogen Interactions and Opportunities for New Antivirals Wednesday February 3 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points Min Chen University of massachusetts Outer Membrane Protein G and Its Application in Biotechnology Wednesday February 10 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points Rebecca Butcher University of Florida Structure Biosynthesis and Mechanism of Small Molecule Signals Controlling Nematode Development Wednesday February 17 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points John MacMillan UT Southwestern Information Rich Screening to Identify Natural Product Scaffolds Wednesday February 24 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points Louis Charles Campeau Merck Discovery and Development of Novel Catalytic Reactions in the Manufacturing of an Active Pharmaceutical Ingredient of ZEPATIER Wednesday March 2 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points Dale Boger Scripps Research Institute Redesign of Vancomycin for Resistant Bacteria Wednesday March 16 2016 12 15 P M 1 15 P M 1220 MRB III View Key Lecture Points Sean Brady Rockefeller University Title TBA Wednesday March 23 2016 12 15 P M 1 15 P M 1220 MRB III Richard Cerione Cornell University Title TBA Wednesday April 6 2016 12 15 P M 1 15 P M 1220 MRB III Meg Phillips UT Southwestern Title TBA Wednesday April 13 2016 12 15 P M 1 15 P M 1220 MRB III Emil Alexov Clemson University Title TBA Wednesday April 20 2016 12 15 P M 1 15 P M 1220 MRB III David Liu Harvard University Title TBA

    Original URL path: http://www.vanderbilt.edu/vicb/events.html (2016-02-16)
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  • Vanderbilt Institute of Chemical Biology
    Schey Claus Schneider Gerald Stubbs Dave Tabb Steven Townsend Michael Waterman John York Bing Zhang Lipid Oxidation in Health and Disease Polyunsaturated fatty acids are a key component of cell membranes These lipids are subject to damage from free radicals generated during normal metabolism and stress responses They are also substrates for enzymes cyclooxygenases and lipoxygenases that add oxygen atoms converting the fatty acids to lipid signaling molecules During both enzymatic and nonenzymatic oxidation of lipids reactive fragments can be generated These lipid electrophiles react with other cellular constituents including DNA and proteins leading to damage that can contribute to disease processes including neurodegenerative diseases obesity cardiovascular disease and cancer A number of VICB members focus their research on understanding the mechanisms of lipid oxidation and its role in both health and disease Research programs include studies of the role of cyclooxygenases and lipoxygenases in cell signaling the DNA and protein targets of lipid electrophile damage novel mechanisms of lipid oxidation and in vivo biomarkers of lipid oxidation The following members have active research programs in lipid oxidation in health and disease Members Alan Brash Richard Breyer Sean Davies Daniel Liebler Larry Marnett Jack Roberts Claus Schneider Natural Products Nature offers a marvelous diversity of chemical structures and many of our valuable therapeutic agents have been derived from natural products Thus there is a growing interest in mining these resources for new drug discovery efforts The chemistry of natural products is often complex and requires specialized synthetic and analytic techniques VICB chemists are meeting this challenge through programs designed to isolate and identify novel natural products to chemically synthesize natural products and to chemically and biochemically alter natural products structures to obtain molecules with optimized bioactivities The following members have active research programs in natural products Members Brian Bachmann Jeff Johnston Craig Lindsley Peter Martin Joseph Parello Gary Sulikowski Steven Townsend Synthetic and Medicinal Chemistry A successful chemical biology program requires a strong foundation in synthetic chemistry Through the Chemical Synthesis Core VICB chemists support research efforts across the entire Vanderbilt Campus But equally important these researchers are actively discovering new reactions and reaction mechanisms that broaden our fundamental understanding of chemistry The following members have active research programs in synthetic and medicinal chemistry Members Kip Guy Eva Harth Jeff Johnston Craig Lindsley Charles Manning Larry Marnett Susan Mercer Wellington Pham Carmello Rizzo Sandy Rosenthal Shaun Stauffer Gary Sulikowski Steven Townsend Alex Waterson New Technologies Chemical biology research strives to apply the latest advances in chemical synthesis and analysis to complex biological systems VICB researchers are at the forefront of developing and applying the latest approaches to the chemistry biology interface such as High Throughput Synthesis and Screening Key to the practice of chemical biology is the discovery of new molecular probes that can be used to investigate the role of specific biochemical and signaling pathways in physiological or pathophysiological processes In addition to providing new insights into critical questions in biology molecular probes also often pave the way for

    Original URL path: http://www.vanderbilt.edu/vicb/research.html (2016-02-16)
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