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  • Shops | VIIBRE | Vanderbilt University
    Steering Committee Scientific Advisory Board Industrial Advisory Board Accomplishments In the News Publications Patents Presentations Portal Links Home Shops Shops The VIIBRE Microfabrication Core facilities include photolithography and soft lithography cleanrooms and equipment as well as very well equipped machine and electronics shops To use our facilities please review the information posted on the New User Information page schedule training with David Schaffer and laboratory bench time through the VUMC C O R E S system Electronics Shop Custom electronic controls and systems are assembled in VIIBRE s Electronics Shop Hakko 936 Solder Station 2 Hakko 703B Rework Station Powerstat 3PF116 AC Power Supply RSR HY3003 3 DC Power Supply Wavetek Model 75A Waveform Generator Wavetek Model 23 Function Generator Energy Concepts 30820A Oscilloscope Yokogawa DL1540 Digital Oscilloscope Machine Shop Many of the devices created in VIIBRE s laboratories require pre or post processing or the addition of enclosures clamps molds or structural systems which can be fabricated in our Machine Shop Tormach PCNC770 CNC Milling Machine with Automatic Tool Changer 3 axes Taig DSLS 3000 CNC Milling Machine 4 Axis Epilog Mini 30W Laser Cutter Engraver Bridgeport Vertical Milling Machine Grizzly DF 1237G 12 Lathe Emco Compact 5 Lathe

    Original URL path: http://www.vanderbilt.edu/viibre/shops.php (2016-02-16)
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  • Cell Culture and Tissue Engineering | VIIBRE | Vanderbilt University
    VIIBRE collaborates with other Vanderbilt University and Medical Center laboratories as well as external institutions to develop various engineered tissue constructs Current research focuses on a range of tissues from blood brain barrier and cardiac tissue on a microfluidic chip to wound repair and scar models We have multiple cell and tissue culture labs available BSL 2 for culture of human primary cells and cell lines Our extensive analytical capabilities which include electrochemical sensor arrays mass spectrometry custom in house engineered and fabricated instrumentation multiple automated fluorescence microscopes and a state of the art confocal HCS HTS microscope enable us to conduct in depth investigations of anything from small bioreactors to large tissue constructs The Cellular Instrumentation and Control Laboratory is dedicated to high bandwidth i e rapid temporal response studies of the dynamics of cellular signaling and metabolism A particular focus is paid towards cell based biosensors and using soft lithographic MEMS fabrication techniques to create silicone based elastomeric Micro and Nanophysiometers that measure simultaneously from a small population of cultured cells in microliter to sub nanoliter cell culture chambers oxygen consumption extracellular pH glucose consumption lactate production amino acid consumption and production and release of specific small molecules

    Original URL path: http://www.vanderbilt.edu/viibre/cell-tissue-culture.php (2016-02-16)
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  • VIIBRE Teams | VIIBRE | Vanderbilt University
    Advisory Board Industrial Advisory Board Accomplishments In the News Publications Patents Presentations Portal Links Home VIIBRE Teams VIIBRE Teams Microfabrication and Organs on a Chip Team Left to right Phil Samson Allison Price Dmitry Markov Jennifer McKenzie Erik Werner Kevin Seale Cheryl Cosby John Wikswo Virginia Pensabene David Schaffer Libby Johnson Ron Reiserer Sarazen Haile Frank Block and Don Berry Seated Vanessa Allwardt The Wikswo team focuses on the development of microfluidic devices and instrumentation to study hybrid silicon biological systems and organs on a chip Electrochemical Sensors and Biosensors Team The Cliffel team is part of the Chemistry Department at Vanderbilt University and the Vanderbilt Institute for Integrative Biosystems Research and Education We focus on electroanalytical measurements in nanoscale and on biological systems as well as synthesis and characterization of gold nanoparticles Biophotonics Biomechanics and Toxicology Team Left to right Alexander Auner Monica Lacy Ty McCleery Sarah Crews Shane Hutson and David Mashburn The central theme of biophotonics is the interaction of biological systems with light The Hutson team is involved in research projects that investigate the physical mechanisms of laser ablation and laser microsurgery We also use these tools to probe the mechanics of biological systems Structural Mass

    Original URL path: http://www.vanderbilt.edu/viibre/teams.php (2016-02-16)
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  • VIIBRE - John P. Wikswo | VIIBRE | Vanderbilt University
    in pioneering magnetic measurements of the magnetoenterogram a non invasive recording of the magnetic field of the electrical activity in the human gastrointestinal tract He then spent a decade exploring the capabilities of superconducting quantum interference device SQUID magnetometers for non destructive testing of plastics and corroding aluminum He is the founding Director of the Vanderbilt Institute for Integrative Biosystems Research and Education VIIBRE which was created in 2001 with a 5 million five year grant from the Vanderbilt Academic Venture Capital Fund to foster and enhance interdisciplinary research in the biophysical sciences bioengineering and medicine at Vanderbilt Within VIIBRE he has focused on building on campus collaborations to use microfabrication to create and utilize devices to instrument and control single cells and small collections of cells and to provide data for parameterization of models of biological processes In the past 13 years VIIBRE has played a central role in bringing to Vanderbilt grants and contracts totaling more than 70 million VIIBRE projects include cellular biosensors nanoliter bioreactors chemotaxis devices and models for cancer research identification of chemical and biological warfare defense agents and infectious pathogens new technologies for tracking metabolic and signaling dynamics and deriving models biomedical imaging biological applications of nanosystems and cellular tissue bioengineering and biotechnology Through each of these projects Wikswo has supported and mentored multiple trainees from the Departments of Biomedical Engineering Molecular Physiology Biophysics and Physics Astronomy VIIBRE coordinates its graduate and postdoctoral training with its Searle Systems Biology and Bioengineering Undergraduate Research Experience SyBBURE Searle a year round multiyear undergraduate research program funded by Gideon Searle These students participate in the full breadth of VIIBRE research activities Wikswo is now focusing his personal research effort on systems biology primarily from the perspective of the optimization of automated systems for combined experimental control and

    Original URL path: http://www.vanderbilt.edu/viibre/wikswo.php (2016-02-16)
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  • John P. Wikswo - Publications | VIIBRE | Vanderbilt University
    Angeles CA May 5 6 2006 Dynamic Cellular Instrumentation and Control for Quantitative Experimental Systems Biology Biodefense and Toxicology Department of Biomedical Sciences Meharry Medical College April 17 2006 Dynamic Cellular Instrumentation and Control for Quantitative Experimental Systems Biology Biodefense and Toxicology Department of Biomedical Sciences Meharry Medical College April 17 2006 The Promise and Challenges of Multianalyte Metabolic Dynamics John Wikswo Franz Baudenbacher David Cliffel Ales Prokop Momchil Velkovsky Vanderbilt University Bela Csukas Kaposvar University Hungary Jerry Jenkins Shankar Sundaram CFD Research Corporation BioLSI 2 Kavli Nanoscience Institute CalTech April 11 2006 The Systems Engineering Problems of Systems Biology Plenary Lecture 38th IEEE Southeastern Symposium on Systems Theory Cookville TN March 6 2006 VIIBRE Dynamic Cellular Instrumentation and Control for Quantitative Experimental Systems Biology Biodefense and Toxicology Oak Ridge Area Director Briefing Vanderbilt University December 12 2005 Systems Biology The Next New Biology Houston Vanderbilt Alumni Club Houston December 1 2005 Metabolic and Signaling Dynamics for Cell Biology Toxin ID and Drug Discovery Systems Biology Department Harvard University Boston October 26 2005 An Update on the Vanderbilt Institute for Integrative Biosystems Research and Education VIIBRE Industrial Practioner Advisory Board for the Department of Biomedical Engineering Vanderbilt University October 25 2005 Cellular and Synthetic Signaling Pathways for Detecting and Classifying Unknown Toxins and Emerging Pathogens UES Kickoff Meeting Dayton October 13 2005 Cellular Metabolic and Signaling Dynamics for Toxin Classification Therapy and Prophylaxis DARPA Cell Signaling Workshop Arlington September 27 2005 Back to the Future Systems Biology as the New Physiology UCSD Center for Theoretical Biological Physics San Diego April 22 2005 The Technical and Computation Challenges of Merging NanoScience and Systems Biology UT Dallas May 4 2005 Integrative Systems for Biotechnology and Bioinformatics A Workshop on Challenges and Opportunities in Integrative Macro Micro and Nano Systems Sponsored by the National Science Foundation Arlington VA March 7 8 2005 Systems Biology The Next New Biology Vanderbilt Alumni Club Nashville TN December 2 2004 The Need for Dynamic Sensing and Control of Cells to Specify and Validate Systems Biology Models Systems Biology Lecture Series University of Michigan Ann Arbor MI November 16 2004 Instrumentation Challenges for Systems Biology Keynote Lecture Third IEEE Sensors Conference Vienna Austria October 26 2004 Correlations Between Single Cell Signaling Dynamics and Protein Expression Profiles DARPA SIMBIOSIS Meeting Vail Colorado October 14 2004 The Need for Cellular and Molecular Sensors and Actuators Mini Symposium Biomolecular Processors through Micro and Nanotechnology 2004 EMBS IEEE Conference San Francisco CA September 2 2004 BioMEMS for Instrumenting and Controlling the Single Cell Workshop on Microanalytical Devices for Bioprocessing 2004 IEEE EMBS Conference San Francisco CA September 1 2004 Measurements versus models in cardiac strong shock response John Wikswo and Marcella Woods 2004 SIAM Conference on the Life Sciences Portland Oregon July 12 2004 From Physics to Medicine Cardiac Complexity and the Challenges of Modeling Multiscale Causality International Conference on Complex Systems ICCS2004 Boston MA May 16 2004 Correlations Between Single Cell Signaling Dynamics and Protein Expression Profiles DARPA Meeting on Real Time Monitoring of Signaling Pathways in Biological Cells Arlington VA April 22 2004 An Overview of the Vanderbilt Institute for Integrative Biosystems Research and Education VIIBRE Industrial Practitioner Advisory Board for the Department of Biomedical Engineering October 21 2003 BioMEMS and the Measurements Needed to Drive Physiological Models Biomedical Engineering Conference Nashville TN October 2 2003 Cardiac Phase in the Spatial or Phase Domains for Identifying Reentrant Behavior and Examining the Response of Cardiac Tissue to Electrical Stimulation John Wikswo and Mark Anthony Bray Gordon Conference on Cardiac Arrhythmia Mechanisms New London NH August 11 2003 The Physics of the Heart Vanderbilt Houston Alumni Club Fall Alumni Luncheon Series December 4 2002 The Physics of the Heart Department of Physics and Applied Physics Joint Colloquium Stanford University November 19 2002 VIIBRE The Vanderbilt Institute for Integrative Biosystems Research and Engineering Vanderbilt University Committee of Visitors Meeting November 15 2002 Experimental and Computational Requirements for Post Genomic Integrative Cellular Physiology Intel Workshop on Early Detection San Francisco CA September 24 2002 The Physics of the Heart Heinz R Pagels Memorial Lecture Aspen Center for Physics Aspen CO August 28 2002 Vacuum Pair Production Annihilation and Cardiac String Dynamics Aspen Center for Physics Aspen CO August 22 2002 Imaging Hidden Corrosion with SQUID Magnetometers Gordon Conference on Aqueous Corrosion New London NH July 14 18 2002 Virtual Electrodes coauthored with Rubin Aliev Mark Anthony Bray Franz Baudenbacher Petra Baudenbacher Veniamin Sidorov Marcella Woods of Vanderbilt University and Brad Roth of Oakland University Cardiostim 2002 Nice France June 20 2002 The Physics of the Heart XXV Encontro Nacional de Fisica de Matéria Condensada Caxambu Brazil May 9 2002 Plenary Models and Measurements of the Anisotropic Cardiac Bidomain Instituto de Matemática Pura e Aplicada Rio de Janeiro Brazil May 6 2002 High Content Toxicology Screening Using Massively Parallel Multi Phasic Cellular Biological Activity Detectors coauthored with Franz Baudenbacher Robert Balcarcel David Cliffel Sven Eklund Jonathan Gilligan Owen McGuinness Todd Monroe Mark Stremler Roy Thompson Ales Prokop and Andreas Werdich DARPA PI Meeting Miami FL February 21 2002 SQUID Imaging of Exfoliation and Intergranular Corrosion coauthored with Yu Pei Ma of Vanderbilt Kevin Cooper of Luna Innovations Inc James Suzel of S K Technologies and Robert Kelly of the University of Virginia Air Force Corrosion Program Office S K Technologies Working Group Meeting Dayton OH November 14 2001 Multiphasic Dynamic High Throughput Measurements and Modeling for Postgenomic Cellular Biophysics and panel discussion on Automating Physiological Data Collection A Link to High Throughput Modelling at the Scientific Scientific Advisory Board Meeting Physiome Inc Princeton NJ November 10 2001 The Magnetocardiogram Tissue Anistropy and the Cardiac Bidomain co authored with Franz Baudenbacher at The Integrated Heart Cardiac structure and function a satellite meeting of the 34th World Congress of the International Union of Physiological Sciences in Queenstown New Zealand August 20 2001 A Multiscale View of Cardiac Electrodynamics The A C Suhren Jr Lecture Series Tulane University New Orleans LA March 29 2001 Cardiac Phase Plane Dynamics During Stimulation and Reentry American Physical Society Seattle March 15 2001 Cardiac Physics How Your Heart Works or Doesn t Nashville Rotary Club Nashville TN February 26 2001 The Physics of the Heart Optical and Magnetic Imaging of Cardiac Activity Theoretical Biophysics Seminar Beckman Institute University of Illinois April 30 2001 Phase and Wave Vector Dynamics During Cardiac Reentry Dynamics Days 2001 Chapel Hill NC hosted by the Duke University Physics Department and the Center for Nonlinear and Complex Systems January 3 6 2001 Recent Results in Electromagnetic and Acoustic Techniques for Non Invasive Detection and Catheter Based Confirmation of Outlet Strut Fracture in the Björk Shiley Heart Valve Bowling Pfizer Supervisory Panel Cincinnati OH January 19 2000 Voltage Calcium and Magnetic Field Imaging Fundamental Studies in Cardiac Excitation Reentry and Defibrillation Vanderbilt Cardiology Group Meeting January 10 2000 Discussion Group A Biodetection Bioassay of Individual Cells Co Chair DARPA Workshop on Nanotechnology for Biodetection Bioassay and Delivery of Therapeutics to Individual Cells Scottsdale AZ December 13 14 2000 Instrumenting and Controlling the Single Cell Patch Clamp to Silicon and Talking to Cells with Light DARPA Workshop on Nanotechnology for Biodetection Bioassay and Delivery of Therapeutics to Individual Cells Scottsdale AZ December 13 14 2000 Magnetic Imaging with SQUIDs Biomagnetism NDE and Corrosion Neocera Beltsville MD June 28 2000 Cardiac Planning Session Vanderbilt University June 26 2000 Review of Iowa Vanderbilt Research on Detection of Outlet Strut Fracture in the Björk Shiley Heart Valve Bowling Pfizer Supervisory Panel Pasadena CA October 27 2000 Cardiac Fibrillation An Challenging Example of Multi Scale Non Linear Biological Modeling Panel on Computational Modeling Simulation of the Dynamic Behavior of Complex Biological Systems and Bio Engineered Systems DARPA FOCUS 2000 Workshop Chantilly Virginia June 28 30 2000 The Challenges of Spatial Scales in Modeling and Understanding Cardiac Fibrillation Chicago World Congress on Medical Physics and Biomedical Engineering and the 22nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society Chicago July 23 28 2000 The Physics of the Heart focus session on measuring and controlling cardiac electrophysiology March meeting of the American Physical Society Minneapolis MN March 23 2000 abstract in The physics of the heart Bull Am Phys Soc 45 1 833 2000 SQUID Microscopes for Magnetic Imaging of Biological Systems Tutorial on Magnetism and Living Systems 44th Annual Conference on Magnetism and Magnetic Materials San Jose CA November 15 1999 An Introduction to DNA and Quantum Computers Department of Physics and Astronomy Vanderbilt University Nashville TN September 2 1999 Potential New Acoustical Techniques for Detecting Single Leg Separation in the Björk Shiley Heart Valve Bowling Pfizer Trust Supervisory Panel Cincinnati OH June 3 1999 A Brief Introduction to DNA and Quantum Computers Hypres Inc Elmsford NY May 27 1999 The Role of Tissue Structure and the Extracellular Space in Propagation North American Society for Pacing and Electrophysiology NASPE Clinical Tutorial on Fundamental Mechanisms of Impulse Propagation From Gap Junctions to Anisotropy Toronto Canada May 13 1999 Cardiac Electrodynamics The Good The Bad and The Non Linear Institute for Theoretical Physics University of California Santa Barbara CA April 28 1999 The Physics of the Heart Plenary Lecture 1998 Summer Meeting of the American Association of Physics Teachers University of Nebraska Lincoln NB August 6 1998 Magnetic Imaging of Cellular Action Currents The Source Field Relationships Electric and Magnetic Fields in Biology and Medicine Sensory Perception Self Organization and Therapeutic Applications Gordon Research Conference on Bioelectrochemistry New England College Henniker NH July 21 1998 The Drug Independent Roles of Cardiac Geometry and Tissue Anisotropy in Defibrillation and Reentry 11th International Congress Cardiostim 98 Nice France June 18 1998 Tissue Anisotropy and Reentry in the Cardiac Bidomain Clinical Tutorial on The Mathematics of Electrophysiology 19th Annual Meeting of the North American Society of Pacing and Electrophysiology NASPE San Diego CA May 7 1998 Novel Insights on the Virtual Electrode Response Optical Mapping of Cardiac Excitation Arrhythmias Scottsdale AZ April 26 1998 Biomedical Applications of SQUIDs Hypres Inc Elmsford NY April 15 1998 Symmetry Silent Sources and Magnetic Imaging with SQUIDs Condensed MatterSeminar University of Minnesota Minneapolis MN April 9 1998 Cardiac Electrodynamics Just How Does Your Heart Work and Why Not Physics Colloquium University of Minnesota Minneapolis MN April 8 1998 High Speed Fluorescence Imaging of Cardiac Action Potentials Confirmation of the Doubly Anisotropic Bidomain Model Biomedical Engineering Seminar University of Minnesota Minneapolis MN April 7 1998 Bioelectric Biomagnetic Phenomena Ion Channels to Organ Function NIH Bioengineering Consortium BECON National Institutes of Health Bethesda MD February 28 1998 SQUID Measurements of the Rate of Hidden Corrosion Technical Interchange Meeting Corrosion Fatigue and Corrosion Predictive Modeling NCI USAF Tinker Air Force Base Oklahoma City OK December 17 19 1997 SQUID Magnetometers for Phase Sensitive Depth Selective Oriented Eddy Current Imaging Quantitative NonDestructive Evaluation QNDE 97 San Diego July 27 August 1 1997 SQUIDs for NDE Methods and Applications NATO Advanced Study Institute on SQUID Sensors Fundamentals Fabrication and Applications Hotel Alexandra Loen Norway June 1997 SQUIDs for Biomagnetism Sources Measurements and Models NATO Advanced Study Institute on SQUID Sensors Fundamentals Fabrication and Applications Hotel Alexandra Loen Norway June 1997 Imaging and Modeling Cardiac Electrical Activity The Need for Multiple Spatial Scales 1997 International Conference on Mathematical Models in Medical and Health Sciences Vanderbilt University Nashville TN May 1997 Cardiac Activation From Uniform Double Layers to the Bidomain Ventritex Sunnyvale CA February 1997 Magnetic Imaging with SQUIDs Department of Physics and Astronomy Vanderbilt University January 1997 Tissue Anisotropy and Re entry in the Heart Cardiology Grand Rounds Vanderbilt University Medical Center Nashville TN December 1996 Biomagnetism and Non Destructive Testing Shared Problems and Solutions Plenary Lecture 1996 Biomagnetism Conference Sante Fe NM February 1996 Experimental and Mathematical Linkages Between Microscopic and Macroscopic Descriptions of Cardiac Electrical Activity Too Many Powers of Ten and the Need for Mesoscopic Models Department of Physics and Astronomy Vanderbilt University November 1995 NDE with SQUIDs Alcoa Technical Center Alcoa Center PA October 1995 Advanced Instrumentation and Measurements for Early Nondestructive Evaluation of Damage and Defects in Aerostructures and Aging Aircraft Air Force 3rd Aging Aircraft Conference Wright Patterson AFB OH September 1995 Recent Developments in 5K Cryocoolers An Outsider s View Closing Summary 5K Cryocooler Workshop Hypres Inc Elmsford NY July 1995 The Two Dimensional Magnetic Inverse Problem NATO Advanced Study Institute on SQUID Sensors Fundamentals Fabrication and Applications Villa del mare Maretea Italy June 1995 Magnetic Imaging of Cellular Action Currents NATO Advanced Study Institute on SQUID Sensors Fundamentals Fabrication and Applications Villa del mare Maretea Italy June 1995 Imaging of Electric and Magnetic Sources NATO Advanced Study Institute on SQUID Sensors Fundamentals Fabrication and Applications Villa del mare Maretea Italy June 1995 Magnetometry North American BioMagnetism Action Group NABMAG Washington DC February 1995 The Theoretical Basis of Biomagnetism NIH Workshop on Developments in Magnetoencephalography as a Functional Imaging Tool Washington DC February 1995 SQUID Magnetometers Applied to Aging Aircraft NDE FAA USAF NASA Aging Aircraft Inspection Workshop on Enhanced Conventional Technologies Ames IA November 1994 SQUID Magnetometers for Biomagnetism and Non Destructive Testing Important Questions and Initial Answers Plenary Lecture Applied Superconductivity Conference Boston MA October 1994 Applications of Superconducting Magnetometry to Aircraft Corrosion Tri Service Conference on Corrosion Orlando FL June 1994 Advanced Instrumentation and Measurements for Early Nondestructive Evaluation of Damage and Defects in Aerostructures and Aging Aircraft Second USAF Aging Aircraft Conference Oklahoma City OK May 1994 The Cardiac Bidomain A Macroscopic Anisotropic Cable Model for Activation and Propagation Duke North Carolina National Science Foundation Engineering Research Center for Emerging Cardiovascular Technologies Defibrillation Workshop Durham NC April 1994 How Do Ventricular Arrhythmias Start Triggers Invited Panelist Cardiac Electrophysiology From Cell to Bedside A Symposium Keystone Resort CO August 1993 Superconducting Magnetometry A Possible Technique for Aircraft NDE Society of Photo Optical Instrumentation Engineers Conference on Nondestructive Inspection of Aging Aircraft San Diego CA July 1993 SQUID Magnetometry for Non Destructive Evaluation Superconductivity Technical Action Group STAG and Contractors Meeting Wright Patterson Air Force Base OH March 1993 Magnetic Imaging of Current and Magnetization Distributions North American BioMagnetism Action Group NABMAG Albuquerque New Mexico January 1993 Electric and Magnetic Imaging of the Cardiac Bidomain The New Information Special Symposium on Cardiac Electrophysiology Computers in Cardiology Conference Durham NC October 1992 Magnetic Susceptibility Imaging for Non Destructive Evaluation Applied Superconductivity Conference Chicago IL August 1992 Fundamental Factors That Affect the EEG and MEG Introductory Talk on the Relationship of the Electroencephalogram and the Magnetoencephalogram EEG MEG Workshop Virginia Beach VA May 1992 Biomagnetic Fields Information and Disinformation A B Learned Professorship in Living State Physics Inaugural Lecture Vanderbilt University October 1991 The Virtual Cathode and Tissue Anisotropy Current Flow in the Cardiac Bidomain and Capabilities and Limitations of Magnetic Measurements of Bioelectric Activity in Nerve and Muscle Mayo Clinic Rochester MN May 1991 A Close View of Patterns of Electrical Current and Nerve in Cortex American Physical Society Cincinnati OH March 1991 Magnetic Measurements of Cellular Action Currents and Magnetic Fields From Steady Bioelectric Currents Ninth International Symposium on Man and His Environment in Health and Disease Dallas TX March 1991 Teaching of Physics to Humanists A Recent Experiment in Raising Students Awareness About How They Think and Learn University Series on Teaching Vanderbilt February 1991 High Resolution SQUIDS for Non Destructive Evaluation Electric Power Research Institute Palo Alto January 1991 Non Destructive Evaluation with SQUIDS and High Resolution Magnetic Imaging for Non Destructive Testing E I Dupont DeNemours Wilmington December 1990 The Vanderbilt University Living State Physics Group A Case Study in Building a State of the Art Research Program Leadership Nashville December 1990 High Resolution SQUIDS for Magnetic Imaging 12th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Philadelphia November 1990 Action Currents and Tissue Anisotropy XVII International Congress on Electrocardiology and the 31st International Symposium on Vectorcardiography Florence Italy September 1990 Bioelectricity and Biomagnetism in the Cardiovascular System Workshop on Bioelectricity and Biomagnetism in Clinical Medicine Little Company of Mary Hospital Torrence April 1990 SQUIDS for NDE Gordon Conference on Non Destructive Testing Ventura March 1990 Biomagnetic Sources and Their Models Tutorial Lecture 7th International Biomagnetism Conference New York August 1989 Applications of SQUIDS to Biomagnetism and Non Destructive Testing Texas Instruments Dallas July 1989 Magnetic Techniques for Evaluating Peripheral Nerve Function Special Symposium on Maturing Technologies and Emerging Horizons in Biomedical Engineering Tenth Annual International Conference of IEEE EMBS New Orleans November 1988 Tract Chair for the Biopotentials Tract Session Chair for Multicellular and Bidomain Systems Nerves and Electric Stimulation and Steady Currents Tenth Annual International Conference of IEEE EMBS New Orleans November 1988 Virtual Cathode Effects and the Cardiac Bidomain Basic Arrhythmia Laboratory Duke University September 1988 Current Distributions in Bisyncytial Tissue World Congress on Medical Physics and Biomedical Engineering San Antonio August 1988 Magnetic Measurements of Action Currents in Bundled Nerves World Congress on Medical Physics and Biomedical Engineering San Antonio August 1988 High Resolution SQUID Magnetometry for Current Imaging Applications to Biophysics and Non Destructive Testing Thomas J Watson Research Ctr IBM Yorktown Heights June 1988 Applications of SQUIDS to Biomagnetism and Non Destructive Testing Hypres Inc Elmsford NY June 1988 High Resolution SQUID Magnetometers for NDE Sensitivity Spatial Resolution and Data Analysis Office of Naval Research SQUID Non Destructive Evaluation Workshop Harper s Ferry April 1988 The Information Content of Biomagnetic Measurements Department of Chemistry and Physics Middle Tennessee State University Murfreesboro November 1987 Magnetic Fields From Action Currents Instrumentation Measurements and Models Department of Chemical Bio and Materials Engineering Arizona State University Tempe September 1987 Finite Element Models for Cardiac Defibrillation Fortieth Annual Conference on Engineering in Medicine and Biology Niagara Falls September 1987 The Biophysics of Neuromagnetism The Beckman Institute University of Illinois Champaign Urbana July 1987 High Resolution Measurements of Biomagnetic Fields 1987 Cryogenic Engineering Conference St Charles Illinois June 1987 Magnetic Fields of Multicellular Systems Ohm s Law Revisited Department of Physics Western Kentucky University November 1986 Multicellular Systems Action Currents and Magnetic Fields 39th Annual Conference on Engineering in Medicine and Biology Baltimore September 1986 Magnetic Measurements of Cellular Action Currents Department of Anatomy and Cellular Biology Emory University June 1986 Magnetic Measurements of Single Axons and Nerve Bundles FASEB Symposium on The Use of Neuromagnetism to Evaluate Normal and Abnormal Nerve Function St Louis April 1986 Session Chair Cellular Biomagnetism Nerves and Hearts Measurements and Models Department of Physics New York University October 1985 Measurements and Modeling of Neuromagnetic Fields 38th Annual Conference on Engineering in Medicine and Biology Chicago September 1985 Magnetic Measurements on Single Nerve Axons and Nerve Bundles Invited Tutorial XIV International Conference on Medical and Biological Engineering and VII International Conference on Medical Physics Espoo Finland August 1985 Modelling of Bioelectric Sources Neuroelectric Phenomena and Neuromagnetism Three invited lectures at a preconference short course at Tampere University of Technology Tampere Finland XIV International Conference on Medical and Biological Engineering and VII International Conference on Medical Physics August 1985 Theoretical Models for Source Localization Panelist Fifth World Conference on Biomagnetism Vancouver August 1984 Magnetocardiography Challenging Clinical Problems and Promising Analytic Techniques Panel Moderator Fifth World Conference on Biomagnetism Vancouver August 1984 Magnetic Measurements of Peripheral Nerve Function Dept of Biomedical Engineering Tulane University New Orleans November 1983 Neuromagnetism A Possible Technique for Surgeons Neurosurgical Grand Rounds LSU Medical Center New Orleans November 1983 Magnetic Field of Nerves and Cardiac Muscle Department of Physics Loyola University New Orleans November 1983 Cellular Magnetism Theory Experiment and Applications Symposium on Frontiers in Electrophysiology 5th Annual Engineering in Medicine and Biology Society Columbus September 1983 The Measurement and Modeling of the Magnetic Field of an Isolated Nerve Axon Spring Meeting of the Am Phys Soc Baltimore April 1983 The ECG MCG Relationship NATO Advanced Study Institute on Biomagnetism Frascati Italy September 1982 Three Lectures on Cellular Action Currents NATO Advanced Study Institute on Biomagnetism Frascati Italy September 1982 Progress in Biomagnetism Dept of Electrical Engineering Tampere University of Technology Tampere Finland August 1982 Opponent Doctoral Thesis Disputation by Timo Varpula Dept of Technical Physics Helsinki University Technology Helsinki Finland August 1982 The Magnetic Field of Nerves Dept of Technical Physics Helsinki University ofTechnology Helsinki Finland August 1982 An Advanced Undergraduate Laboratory in Living State Physics Southeast Section of the American Physical Society New Orleans 1981 The Magnetic Field of Nerves Dept of Physics Illinois Institute of Technology Chicago 1981 Forward and Inverse Problems in Electrocardiography and Magnetocardiography 34th Annual Conference for Engineering in Medicine and Biology Houston 1981 Session Chair The Magnetic Field of Nerves AAPT Summer Meeting Stevens Point Wisc 1981 Recent Developments in the Measurement of Magnetic Fields From Isolated Nerves and Muscles Magnetism and Magnetic Materials Conference Dallas 1980 Measurement of the Magnetic Field of Isolated Nerves Conference of the Engineering in Medicine and Biology Society Washington 1980 The Measurement of the Magnetic Field of Nerves Dept of Physics University of Alabama Birmingham 1979 The Measurement and Meaning of Biomagnetic Fields Sigma Xi United States Naval Academy 1979 The Meaning of the Magnetocardiogram Southeast Section of the American Physical Society Blacksburg 1978 Magnetocardiography Bio Engineering Seminar University of Minnesota 1978 Clinical Magnetocardiography Non Invasive Cardiovascular Measurements Conference Stanford University 1978 back to top Reports Life Sciences Modeling Strategic Planning Final Report Vanderbilt University January 7 2007 http dbmichair mc vanderbilt edu lsm Peter Cummings and Daniel Masys co chairs Vito Quaranta Glenn Webb Thomas Weiler and John Wikswo A Strategic Academic Plan for the College of Arts and Science 2001 A Report to Dean John H Venable by the Senior Steering Council for the Strategic Academic Plan College of Arts and Science SAP CAS 225 pages http www vanderbilt edu AnS strategic Testing of Stator Windings for Thermal Aging Y P Ma and J P Wikswo Jr EPRI 1000376 Final Technical Report Electric Power Research Institute 2000 Appointments Promotion and Tenure 1997 A Report to the Provost by the Committee on Appointments Promotion and Tenure CAPT 200 pages High Resolution Superconducting Magnetometry for Nondestructive Evaluation W G Jenks Y P Ma and J P Wikswo Jr EPRI TR 108649 Final Report Electric Power Research Institute 1997 SQUID Detection of Deep Flaws in Aluminum Plates Y P Ma and J P Wikswo Jr Report VEL1996 2 Alcoa Technical Center 1996 An In depth Review of the Vanderbilt University Patent Policy and Recommendations for its Replacement by a Policy on Technology and Literary and Artistic Works Vanderbilt University Patent Committee 1993 63 pages Reintroducing Introductory Physics C Kurtz G Ray J Wells and J P Wikswo Jr Department of Physics and Astronomy Vanderbilt University 1992 Imaging of Small Defects in Nonmagnetic Tubing Using a SQUID Magnetometer D C Hurley Y P Ma S Tan and J P Wikswo Jr Manufacturing Technologies Laboratory 92CRD072 G E Research Development Center 1992 The Physics of Technology A Hypercard Approach J P Wikswo Jr and C T Black Eds Department of Physics and Astronomy Vanderbilt University 1990 Report of the College Ad Hoc Committee on the Microcomputer Store J P Wikswo Department of Physics and Astronomy Vanderbilt University 1988 An Intermediate Physics Laboratory J P Wikswo Jr and M S Webster Eds Department of Physics and Astronomy Vanderbilt University 1988 Application of Adaptive Filters to Enhancement of Geomagnetic Data M C Leifer J P Wikswo Jr and E J Iufer Department of Physics Stanford University and the NASA Ames Research Interchange 1981 An Advanced Undergraduate Laboratory in Living State Physics J P Wikswo Jr B Vickrey and J H Venable Jr Department of Physics and Astronomy Vanderbilt University 1980 Application of Sensitivity Vectors to the Measurement and Modeling of Magnetostatic Fields J P Wikswo Jr Report PAS 79 1 David W Taylor Naval Ship Research and Development Center Bethesda 1979 A Guide to Scalar Multipole Expansions J P Wikswo Jr Report PAS 78 36 David W Taylor Naval Ship Research and Development Center Bethesda 1978 Non Invasive Magnetic Measurement of the Electrical and Mechanical Activity of the Human Heart J P Wikswo Jr Ph D Dissertation Dept of Physics Stanford University 1975 Magnetic Shielding and the Adjustment of Remanence J P Wikswo Jr Stanford Low Temperature Physics Group Report SLTP 1972 2 1972 back to top Conference Proceedings Davis LM Canfield BK Germann JA King JK Robinson WN Dukes III AD Rosenthal SJ Samson PC Wikswo JP Four Focus Single Particle Position Determination in a Confocal Microscope In Single molecule spectroscopy and imaging III Proceedings SPIE Vol 7571 Enderlein J and Gryczynski Z eds SPIE Bellingham WA 757112 2010 Davis LM Canfield BK Li X Hofmeister WH Shen G Lescano I Bomar BW Wikswo JP Markov DA Samson PC et al Electrokinetic Delivery of Single Fluorescent Biomolecules in Fluidic Nanochannels Proc SPIE 7035 70350A 2008 Kim EGR Sivasubramaniam P Wikswo JP Seale KT Differential Optical Flow for Automated Cell Motility In Micro total analysis systems 2008 proceedings of the mTAS 2008 Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences Locascio LE ed Chemical and Biological Microsystems Society San Diego CA 1831 1833 2008 Irimia A Gallucci M Wikswo J Comparison of Chaotic Biomagnetic Field Patterns Recorded From the Arrhythmic Cardiac and GI Systems Sixth International Conference on Complex Systems June 25 30 Boston MA 2006 Ma YP Wikswo JP Juzeliunas E Remote Detection of Corrosion Activity by SQUID Magnetometry Across a Multiphase Medium Under Electrolyte Flow Conditions Corros Sci 47 621 633 2005 Prokop A Prokop Z Schaffer D Kozlov E Wikswo JP Cliffel D Baudenbacher F NanoLiterBioReactor Monitoring of Long Term Mammalian Cell Physiology at Nanofabricated Scale In Biological and Bioinspired Materials and Devices Aizenberg J Orme C Landis WJ Wang R eds MRS 2004 Bradshaw LA Roy OP Myers AG McDowell JG Wikswo JP Richards WO Identification of Magnetic Field Injury Currents in Ischemic Small Intestine In Biomag 2004 Proceedings of the 14th International Conference on Biomagnetism August 8 12 Halgren E ed Biomag 2004 Boston Mass 270 2004 Bradshaw LA Sims JA Jordan P Wikswo JP Richards WO Vector Analysis of Gastrointestinal Biomagnetic Fields Proceedings of the Annual International Conference IEEE EMBS Cancun Mexico 4 3275 3278 2003 Baudenbacher F Monroe WT Werdich A Cliffel D Wikswo JP The Nanophysiometer BioMEMS for High Bandwidth Detection of Cellular Activity in Subnanoliter Volumes Proceedings of the Second Joint EMBS BMES Annual Conference Houston TX 2 1690 1691 2002 Skennerton G Wikswo JP Kelly RG Abedi A Magnetic Measurements of the Response of Corrosion Activity Within Aircraft Lap Joints 5th Joint NASA FAA DoD Conference on Aging Aircraft Kissimmee FL 2001 Ma YP Wikswo JP Fitzpatrick G SQUID Measurements of Magnetization for a Magnetically Tagged Composite Material Rev Prog Quant Nondestr Eval 20A 1831 1836 2001 SQUID Measurements for Thermal Aging of Stator Windings Rev Prog Quant Nondestr Eval 20A 369 376 2001 Bradshaw LA and Wikswo JP Jr Inverse Imaging of Distributed Oscillatory Activity In Biomag 96 proceedings of the tenth international conference on biomagnetism Santa Fe NM Aine CJ Okada YC Stroink G Swithenby SJ eds Springer 923 926 2000 Bradshaw LA Allos SH Wikswo JP Jr Richards WO Magnetic Field Measurement of Rabbit Colonic Electrical Activity In Biomag 96 proceedings of the Tenth International Conference on Biomagnetism Santa Fe NM Aine CJ Okada YC Stroink G Swithenby SJ eds Springer 608 611 2000 Ribeiro EP Wikswo JP Jr Ribeiro PC Szczupak J Magnetic Susceptibility Tomography With Nonuniform Field In Biomag 96 Proceedings of the 10th international conference on biomagnetism Santa Fe NM Aine CJ Okada YC Stroink G Swithenby SJ eds Springer New York 671 674 2000 Staton DJ Allos SH Henry VK Bradshaw LA Ladipo JK Richards WO Wikswo JP Jr Noninvasive Measurement of the Vector Magnetic Field From Human Gastrointestinal Sources In Biomag 96 proceedings of the Tenth International Conference on Biomagnetism Santa Fe Aine CJ Okada YC Stroink G Swithenby SJ eds Springer 635 638 2000 Barbosa CH Bruno AC Vellasco M Pacheco M Wikswo JP Jr Ewing AP Camerini CS Automation of SQUID Nondestructive Evaluation of Steel Plates by Neural Networks IEEE Transactions on Applied Superconductivity 9 3475 3478 1999 Barbosa CH Lima EA Bruno AC Ewing AP Wikswo JP Jr Flux Voltage Calibration of Axial SQUID Gradiometers Using an Optimization Procedure IEEE Trans on Applied Superconductivity 9 2 3523 3526 1999 Bray M A Lin S F Wikswo JP Jr Panoramic Epifluorescent Visualization of Cardiac Action Potential Activity Proceedings of SPIE 3658 99 107 1999 Moya A Baudenbacher FJ Wikswo JP Jr Wellstood FC Design of High Resolution HTS SQUID Magnetometers for Biomagnetic Imaging IEEE Transactions on Applied Superconductivity 9 3511 3514 1999 Ribeiro EP Wikswo JP Jr Ribeiro PC Susceptibility Tomography Versus Current Density Reconstruction Comparing the Singular Values In Recent Advances in Biomagnetism Proceedings of the 11th International Conference on Biomagnetism Yoshimoto T Kotani M Kuriki S Karibe H Nakasato N eds Tohoku University Press Sendai Japan 286 289 1999 Bradshaw LA and Wikswo JP Jr Vector or Scalar Magnetometer Arrays Proceedings of the First Joint BMES EMBS Conference Atlanta GA 2 888 1999 Barbosa CH Bruno AC Kuhner GS Wikswo JP Jr Ewing AP Ma YP Camerini CS Measurements of Surface Breaking Flaws in Steel Pipes Using a SQUID Susceptometer in an Unshielded Environment Review of Progress in Quantitative Nondestructive Evaluation 17A 1091 1097 1998 Ewing AP Cruse TA Wikswo JP Jr A SQUID NDE Measuement Model Using BEM Review of Progress in Quantitative Nondestructive Evaluation 17A 1083 1090 1998 Ewing AP Barbosa CH Cruse TA Bruno AC Wikswo JP Jr Boundary Integral Equations for Modeling Arbitrary Flaw Geometries in Electric Current Injection NDE Review of Progress in Quantitative Nondestructive Evaluation 17A 1011 1015 1998 Ma YP and Wikswo JP Jr SQUID Magnetometers for Depth Selective Oriented Eddy Current Imaging Review of Progress in Quantitative Nondestructive Evaluation 17A 1067 1074 1998 Bradshaw LA Ladipo JK Wikswo JP Jr Richards WO The Vector Magnetic Field of the Human Stomach and Small Bowel Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society v 6 2390 2391 1997 Bradshaw LA Wells R Paul S Richards WO Wikswo JP Jr Noninvasive Measurement of Gastric Propagation Using a SQUID Magnetometer Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society v 6 2392 2393 1997 Ewing AP Wikswo JP Jr Cruse TA Probability of Detection POD in SQUID NDE Proceedings of the 1st Joint DoD FAA NASA Aging Aircraft Conference Ogden UT 8 10 July 1997 Ewing AP Barbosa CH Cruse TA Bruno AC Wikswo JP Jr Boundary Integral Equation Measurement Model for Electric Current Injection Method of Nondestructive Evaluation COMPUMAG The 11th Conference on the Computation of Electromagnetic Fields PA4 6 88 90 1997 Ladipo JK Bradshaw LA Hegde SS Wikswo JP Jr Richards WO In Vivo Dection of Normal and Pathologic Bowel Electrical Activity Using a Squid Magnetometer Proceedings ot the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society v 6 2388 2389 1997 Wikswo JP Jr SQUID Magnetometers for Studying Corrosion and Corrosion Protection in Aircraft Aluminum Corrosion 97 Annual Conference of NACE International Paper 293 1 17 1997 Jenks WG Ball B Cadzow JA Cruse T Ewing AP Hahn G Li X Ma YP Wikswo JP Jr Recent Advances in SQUID Magnetometers for Aging Aircraft NDE 4th Air Force Aging Aircraft Conference 843 849 1996 Ma YP and Wikswo JP Jr Depth Selective SQUID Eddy Current Techniques for Second Layer Flaw Detection Review of Progress in Quantitative Nondestructive Evaluation 15 401 408 1996 Ma YP and Wikswo JP Jr SQUID Magnetometers for Nondestructive Testing and Biomagnetism Proceedings of 1996 Chinese American Academic and Professional Convention CAAPCON 4 17 1 4 17 4 1996 Staton DJ Rousakov SV Wikswo JP Jr Conductivity Imaging in Plates Using Current Injection Tomography Review of Progress in Quantitative Nondestructive Evaluation 15 845 851 1996 Abbas RA Lin S F Wikswo JP Jr Optical Imaging of Activation Patterns in Rabbit Myocardium Proceedings of the 17th Annual International Conference of the IEEE EMBS Basic and Applied Biomedical Engineering Building Blocks for Health Care v 17 CD ROM 1995 Bradshaw LA and Wikswo JP Jr Autoregressive and Eigenfrequency Spectral Analysis of Magnetoenterogreaphic Signals Proceedings of the 17th Annual International conference of the IEEE EMBS Basic and Applied Biomedical Engineering Building Blocks for Health Care 17 CD ROM 1995 Bradshaw LA Garrard CL Allos SH Wikswo JP Jr Richards WO Magnetoenterography for Detection of Intestinal Ischemia in Rabbits Proceedings of the 17th Annual International Conference of the IEEE EMBS Basic and Applied Biomedical Engineering Building Blocks for Health Care 17 CD ROM 1995 Bruno AC Ewing AP Wikswo JP Jr Measurements of Surface Breaking Flaws in Ferromagnetic Plates by Means of an Imaging SQUID Susceptometer IEEE Transactions on Applied Superconductivity 5 2482 2485 1995 Jenks WG Ma YP Wikswo JP Jr SQUID Magnetometers for Electromagnetic NDE in the Electric Power Industry Epri Topical Workshop Electromagnetic NDE Applications in the Electric Power Industry Session 3 21 23 1995 Richards WO Staton DJ Golzarian J Friedman RN Wikswo JP Jr Non Invasive SQUID Magnetometer Measurement of Human Gastric and Small Bowel Electrical Activity In Biomagnetism Fundamental research and clinical applications the 9th International Conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdam Netherlands Vol 7 pp 743 747 1995 Richards WO and Wikswo JP Jr Gastrointestinal System Physiology Pathology and Possibilities for Biomagnetic Diagnosis Biomagnetism Fundamental Research and Clinical Applications 7 732 738 1995 Staton DJ and Wikswo JP Jr Magnetic Imaging of Currents in Two dimensional Cardiac Tissue Experimental and Theoretical Studies of Electrical Activity in Mammalian Cardiac Slices In Biomagnetism Fundamental Research and Clinical Applications Proceedings of the 9th International conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdamp v 7 647 651 1995 Staton DJ Golzarian J Wikswo JP Jr Friedman RN Richards WO Measurements of Small Bowel Electrical Activity in Vivo Using a High Resolution SQUID Magnetometer In Biomagnetism Fundamental Research and Clinical Applications Proceedings of the 9th International Conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdam 7 748 752 1995 Staton DJ and Wikswo JP Jr High Resolution Imaging of Magnetic Fields From Injected and Action Currents in Slices of Anisotropic Cardiac Tissue In Biomagnetism Fundamental Research and Clinical Applications Proceedings of the 9th International Conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdam Vol 7 pp 684 687 1995 Staton DJ and Wikswo JP Jr Magnetic Inverse Method for Determination of Anisotropic Electrical Conductivities in a Two Dimensional Cardiac Bidomain In Biomagnetism Fundamental Research and Clinical Applications Proceedings of the 9th International Conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdam v 7 671 675 1995 Wikswo JP Jr Sepulveda NG Thomas IM Three Dimensional Biomagnetic Imaging With Magnetic Susceptibility Tomography Biomagnetism Fundamental Research and Clinical Applications Proceedings of the 9th International Conference on Biomagnetism Baumgartner C Deecke L Stroink G Williamson SJ eds IOS Press Amsterdam 7 780 784 1995 Wikswo JP Jr Closing Comments Recent Developments in 5K Cryocoolers An Outsiders View 5 K Cryocooler Workshop Present Status Future Prospects and Market Potential for 4 5 K Cryocoolers Proceedings Elmsford NY 58 66 1995 Bradshaw LA Wijesinghe RS Wikswo JP Jr A Spatial Filtering Forward and Inverse Model of EEG and MEG Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society Engineering Advances New Opportunities for Biomedical Research Baltimore 16 167 168 1994 Li D Ma YP Flanagan WF Lichter BD Wikswo JP Jr The Use of Superconducting Magnetometry to Detect Corrosion in Aircraft Alloys Proceedings of the Tri Service Conference on Corrosion Orlando 335 346 1994 Ma YP and Wikswo JP Jr SQUID Eddy Current Techniques for Detection of Second Layer Flaws Review of Progress in Quantitative Nondestructive Evaluation 13 303 309 1994 Wikswo JP Jr SQUID Magnetometers Applied to Aging Aircraft NDE Proceedings of the Joint USAF NASA FAA Aging Aircraft NDI Workshop Covering Research

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  • John P. Wikswo - Research Interests | VIIBRE | Vanderbilt University
    1991 my group had found the desired field pattern and devised magnetic imaging algorithms that have become the gold standard in the field We recognized that the same instrumentation scanning stages and analysis algorithms could detect flaws in metals and plastics and we mounted a 10 year program that was funded by the Air Force Office of Scientific Research AFOSR private industry and the German government This work evolved into an AFOSR sponsored initiative and produced the only technique yet known that can measure the instantaneous rate of corrosion occurring inside an aging aircraft lap joint This work in turn attracted long term support from the Air Force As our understanding grew we found that the mathematical models of electrically and magnetically silent fields applied not only to cardiac muscle but also riveted aluminum Meanwhile with colleagues in the Medical Center I began measuring cardiac conduction velocity during ischemia and infarct and in the presence of antiarrhythmic drugs During one of these experiments I recognized the existence of virtual cathodes in cardiac tissue which happened to be related to the same anisotropy differences that produced the magic magnetic fields The cardiac community paid little notice until my collaborators and I showed that these anisotropy differences and associated virtual cathodes and anodes could explain an old puzzle in cardiac electrophysiology produce a previously unrecognized form of cardiac reentrant activation and provide key mechanisms for understanding the success or failure of cardiac defibrillation This work also led us into the non linear dynamics of cardiac stimulation The continuing exploration of biomagnetic measurements picked up another first the magnetic field of intestinal smooth muscle which has spawned a large well funded and productive collaboration with Bill Richards and Alan Bradshaw that is developing SQUID measurements into the first non invasive clinical tool for the diagnosis of acute mesenteric ischemia and other gastrointestinal disorders The quest for the higher spatial resolution SQUIDs led me to recruit Franz Baudenbacher to lead an NSF and NIH funded project that has produced the world s best SQUID microscope and used it in an experiment in collaboration with a geobiology group at Caltech to characterize the thermal history of a Martian meteorite from its magnetic signature and show that material could be transported from Mars to earth without sterilization This NanoSQUID has the potential to revolutionize the magnetic measurement of geophysical samples and it allowed us to record beautiful data of the electrically silent magnetic fields of currents propagating through cardiac tissue made possible by productive excursions into geophysics and NDE In 2000 I decided that I wanted to refocus my interests toward biology and with the support of a 5 million five year grant from the Vanderbilt Academic Venture Capital Fund I founded the Vanderbilt Institute for Integrative Biosystems Research and Education VIIBRE to foster and enhance interdisciplinary research in the biophysical sciences bioengineering and medicine at Vanderbilt This effort has been highly successful and it has led to the development of a diverse set of microfluidic

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  • John P. Wikswo - Teaching | VIIBRE | Vanderbilt University
    Virginia I had another remarkable mentor in Professor Bascom Deaver who hired me as a technician to equip his new low temperature physics laboratory guided me as I taught myself experimental physics and encouraged me to work with his mentor at Stanford William Fairbank My belief in learning by doing and by teaching was deepened when my wife and I taught our children at home for a few years I observed not only the various ways that humanists and scientists approach the world but also how different people think and learn Watching our children explain things to each other and their friends convinced me that students learn by explaining I can even cite professional pedagogical influences such as Richard Light s The Harvard Assessment Seminars which I often require my students to read and Sheila Tobias They re not Dumb They re Different My interdisciplinary research has always been reflected in my classroom teaching In addition to teaching such courses as Advanced Laboratory in Mechanics and Heat Medical Physics Electricity and Magnetic Fields General Physics Bioelectricity Elementary Physics Biophysical Electrodynamics Principles of Physics Practical Physics Introduction to Applied Physics and Electricity Magnetism and Electrodynamics to undergraduates I have developed new demonstrations for premed introductory courses taught medical physics to biomedical engineers and electricity and magnetism to senior physics undergraduates and incoming graduate students I have enlisted undergraduates to develop course materials the largest such project being an Advanced Undergraduate Laboratory in Living State Physics supported by NSF and Vanderbilt As my interdisciplinary research has expanded into new areas so has my teaching In 2003 I received a Whitaker Special Opportunity Award Instrumenting and Controlling the Single Cell An Education Program in Biomedical Engineering that supported two new faculty members and created new courses I have participated in Vanderbilt s College Scholars Honors Seminars Program since it was begun more than 20 years ago leading undergraduate seminars that explore such topics as Scientific Revolutions Physics of Technology and most recently What is Life and Why is Biology Complex The last two classes have enrolled a wonderful mix of science humanities and engineering students who undertake critical and extensive readings guided by a Socratic dialogue and complemented with student led presentations From the beginning of my career I have enriched my research endeavors with a steady stream of some of Vanderbilt s brightest most energetic students and postdocs from physics chemistry biology medicine and electrical mechanical and biomedical engineering and continually taught them to communicate across disciplines In establishing VIIBRE I maintained a strong focus on undergraduate graduate and postdoctoral education and through each of VIIBRE s projects in innovative technologies I have supported and or mentored multiple trainees from across the physical and biomedical sciences On the undergraduate level the most visible evidence of this effort is the Systems Biology and Bioengineering Undergraduate Research Experience SyBBURE a major program funded by Vanderbilt alumnus Gideon Searle with the goal to provide undergraduate students as early as possible in their academic careers with

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  • David Cliffel | Department of Chemistry | Vanderbilt University
    We are developing new multianalyte microphysiometry methods with applications in cancer diabetes and toxicology We have added electrochemical detectors for many metabolic analytes into the microfluidic chamber to give a complete dynamical picture of the live cell population Nanoparticle Biomimics The ability to mimic biomolecular recognition requires the generation of nanoscale structures that faithfully reproduce the lock key motif of protein binding We have designed biomimics that present targeted linear and loop peptide structures on the surface of monolayer protected gold nanoparticles These biomimics are useful for calibrating immunoassays especially in our immunosensor work with the quartz crystal microbalance Electrochemistry on the Nanoscale Electron transfer in nanometer size chemical systems is an important process for the creation of macromolecular electronics We are interested in the electrochemistry of metallic nanoparticles redox proteins like Photosystem I and other electroactive nanomaterials that bridge the gap between bulk solids and discrete molecules in the development of electronic devices using nanotechnology GO Selected Publications Venmar KT Kimmel DW Cliffel DE Fingleton B IL4 receptor α mediates enhanced glucose and glutamine metabolism to support breast cancer growth Biochimica et Biophysica Acta 2015 4 1853 5 1219 1228 Casey MC Cliffel DE Surface adsorption and electrochemical reduction of 2 4 6 trinitrotoluene on vanadium dioxide Analytical Chemistry 2015 87 1 334 7 Lima EA Snider RM Reiserer RS McKenzie JR Kimmel DW Eklund SE Wikswo JP Cliffel DE Multichamber Multipotentiostat System for Cellular Microphysiometry Sensors and Actuators B Chemical 2014 204 536 543 Darby E LeBlanc G Gizzie EA Winter KM Jennings GK Cliffel DE Photoactive films of photosystem I on transparent reduced graphene oxide electrodes Langmuir the ACS journal of surfaces and colloids 2014 30 29 8990 4 Leblanc G Gizzie E Yang S Cliffel D E Jennings G K Photosystem I Protein Films at Electrode Surfaces for Solar Energy Conversion Langmuir 2014 0 0 Epub ahead of print Gunther D LeBlanc G Prasai D Zhang J R Cliffel D E Bolotin K I Jennings G K Photosystem I on Graphene as a Highly Transparent Photoactive Electrode Langmuir 2013 29 13 4177 4180 Wikswo J P Block F E Cliffel D E Goodwin C R Marasco C C Markov D A McLean D L McLean J A McKenzie J R Reiserer R S Samson P C Schaffer D K Seale K T Sherrod S D Engineering Challenges for Instrumenting and Controlling Integrated Organ on Chip Systems IEEE Transactions on Biomedical Engineering 2013 60 3 682 690 Kimmel D W Dole W P Cliffel D E Application of multianalyte microphysiometry to characterize macrophage metabolic responses to oxidized LDL and effects of an apoA 1 mimetic Biochemical and Biophysical Research Communications 2013 431 2 181 185 Simpson C A Salleng K J Cliffel D E Feldheim D L In vivo toxicity biodistribution and clearance of glutathione coated gold nanoparticles NanoMedicine NanoTechnology Biology and Medicine 2013 9 2 257 263 Harkness K M Turner B N Agrawal A C Zhang Y B McLean J A Cliffel D E Biomimetic

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