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  • News and Announcements - Division of Research

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    Original URL path: /news.php?id=5312 (2016-02-13)



  • News and Announcements - Division of Research
    develop algorithms analysis and system design tools for integrating and consolidating multiple subsystems on a shared processing platform Also he will design curriculum and an outreach program aimed at increasing recruitment of students to the field of embedded systems programs and research with a focus on underrepresented groups Embedded systems are computer systems designed to perform one or a few functions often with real time computing constraints As seen with the rise of smart phones MP3 players and the complex computers built into cars and airplanes the demand for more applications on a single device has led to an increase in multiple subsystems operating on shared processing platforms Virtualization execution environments VEE technologies enable consolidation and permit embedded systems to be designed with reduced size weight and power over non integrated systems VEEs still hold many challenges however such as allocating a shared processing platform s computational resources to many subsystems and ensuring all timing requirements are met When you re working with multiple embedded subsystems that have competing computational deadlines it is essential to isolate the effect of one subsystem against the others because if one subsystem takes up too much processing time the other deadlines won t be met To address the problem Fisher is developing algorithms for real time subsystem scheduling that maximize the use of resources with the VEE framework He also is developing a resource sharing protocol between subsystems developing system design tools and designing the first techniques for verifying the timeliness of VEEs The project includes a substantial education component aimed at increasing awareness of embedded and real time system design to students of all academic levels with a focus on underrepresented groups The work will provide materials sufficient for at least two Ph D dissertations an undergraduate research project developing a robotics based

    Original URL path: http://research.wayne.edu/news.php?id=5263 (2016-02-13)
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  • News and Announcements - Division of Research
    On Oct 19 2010 the National Institute of Allergy and Infectious Diseases NIAID of the National Institutes of Health NIH announced four contracts to address antimicrobial resistance including an award to Wayne State University for the project Targeted Clinical Trials to Reduce the Risk of Antimicrobial Resistance The first year of funding for this grant is 2 8 million with an anticipated total of 12 8 million over the course of the contract if all project milestones are met Keith S Kaye M D M P H professor of internal medicine and infectious diseases in WSU s School of Medicine and corporate director of Infection Prevention Hospital Epidemiology and Antimicrobial Stewardship at the Detroit Medical Center will lead this multi center study that will examine the antimicrobial therapy of multi drug resistant Acinetobacter baumannii a major cause of bloodstream infection and pneumonia in health care settings The study involves four health care systems in Southeastern Michigan and the Detroit Medical Center will serve as the central campus for the project The study will investigate colistin a relatively old and toxic antimicrobial agent which clinicians have been forced to use more frequently to treat bacteria that are resistant to all other available antibiotics Various aspects of colistin therapy including clinical outcomes toxicity pharmacokinetics and emergence of resistance will be analyzed during the study period This contract is part of NIH s response to the growing threat and spread of antimicrobial resistance said Dr Kaye Infections due to health care associated pathogens such as Acinetobacter are becoming increasingly common and difficult to treat In some cases colistin is the only active antimicrobial agent available for treatment of these resistant infections The goal of this project is to improve the medical community s understanding of colistin and provide clinicians with much needed guidance

    Original URL path: http://research.wayne.edu/news.php?id=5256 (2016-02-13)
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  • News and Announcements - Division of Research

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    Original URL path: /news.php?id=5235 (2016-02-13)


  • News and Announcements - Division of Research
    Biological Chemistry for a study that identified a novel mechanism associated with the regulation of intracellular levels of PtdIns 3 5 P2 a signaling lipid critical in neurodegeneration CMT4J is a recessively inherited disorder in which patients slowly lose normal use of their feet legs hands and arms as nerves to the extremities degenerate and the muscles in the extremities become weakened due to the loss of stimulation by the affected nerves Many patients also have some loss of sensory nerve function A 2007 University of Michigan study published in Nature found that the enzyme that destroys PtdIns 3 5 P2 known as Sac3 is mutated in patients with peripheral neuropathy hence the CMT4J disorder This mutation involves a single amino acid substitution at position 41 i e Sac3I41T and results in a variation of the protein Sac3 which is present as a single allele patients are missing the other allele altogether With this study we set out to discover what happens differently because of this mutation and if this I to T amino acid substitution is related to changes in intracellular PtdIns 3 5 P2 regulatory mechanisms Shisheva said The study found that the Sac3 s mutant form Sac3I41T does not have the ability to sense the presence of ArPIKfyve a scaffold protein that as Shisheva s lab discovered and reported in the current accelerated publication exhibits the property to protect normal Sac3 from rapid degradation Because Sac3I41T is degraded too quickly optimal synthesis of PtdIns 3 5 P2 cannot occur We don t yet know why this is but we believe this rapid degradation of Sac3I41T may be the cause of CMT4J Shisheva said The current findings are the most recent in a decade long line of research on the regulation of PtdIns 3 5 P2 metabolism by

    Original URL path: http://research.wayne.edu/news.php?id=5232 (2016-02-13)
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  • News and Announcements - Division of Research

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    Original URL path: /news.php?id=5313 (2016-02-13)


  • News and Announcements - Division of Research
    many of whom were destined to develop cognitive decline within 18 months of testing John Woodard Ph D associate professor of psychology in the College of Liberal Arts and Sciences and Institute of Gerontology at Wayne State University is lead author of Predicting Cognitive Decline in Healthy Older Adults Using fMRI published in the current Journal of Alzheimer s Disease vol 21 no 3 No one had studied these combinations of tests in such a large sample Woodard said The results have strong implications for determining who is most likely to benefit from preventive Alzheimer s disease treatments Woodard and his colleagues performed five tests on 78 healthy elders a structural MRI sMRI that measures the size of the hippocampal region of the brain a functional MRI fMRI that shows how the brain is activated during mental tasks a blood test that identifies the APOE ε4 allele a known genetic marker for Alzheimer s disease and two standard neuropsychological tests that measure mood and ability The most effective combination of tests to predict near term cognitive decline was the fMRI and the APOE ε4 test The APOE ε4 allele alone correctly classified 61 5 percent of participants but the combination of the ε4 allele and low activity on the fMRI test correctly classified 78 9 percent of participants including 35 percent who showed significant cognitive decline 18 months post testing Age years of education gender and family history of dementia were not accurate predictors of future cognitive decline Dr Woodard and his colleagues also found that persons with larger hippocampal volume greater functional brain activity and no APOE ε4 allele were less likely to demonstrate cognitive decline over the following 18 months The APOE and fMRI tests that combined as the best predictors are readily available not time consuming and

    Original URL path: http://research.wayne.edu/news.php?id=5236 (2016-02-13)
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  • News and Announcements - Division of Research

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    Original URL path: /news.php?id=5097 (2016-02-13)