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  • News and Announcements Archive - Nano@Wayne - Division of Research
    s team revealed that if the Sac3 enzyme is not bound and protected by ArPIKfyve it is prone to a quick demise inside the cell In addition they found that this double ArPIKfyve Sac3 protein complex is a part of a bigger triple assembly incorporating the PIKfyve enzyme as well The triple complex controls the production and turnover of one rare phospholipid molecule that controls the traffic of membranes towards the digestive system of the cell It has remained a mystery why the Sac3 mutations are associated with neurodegeneration in humans whereas the human mutations in PIKfyve are currently linked only to a relatively benign disease of the cornea This led Shisheva s team to believe that the double ArPIKfyve Sac3 complex has separate functions in the brain Shisheva s group sought to identify brain specific proteins that physically interact only with the double complex ArPIKfyve Sac3 In a recent paper The protein complex of neurodegeneration related phosphoinositide phosphatase Sac3 and ArPIKfyve binds the Lewy body associated Synphilin 1 preventing its aggregation published online in the Journal of Biological Chemistry Shisheva and her research team characterized a novel interaction partner of the ArPIKfyve Sac3 complex in the brain The Journal of Biological Chemistry is the world s largest and most cited journal based on PageRank algorithm We uncovered that the ArPIKfyve Sac3 complex binds Synphilin 1 a protein already implicated in the pathogenesis of Parkinson s disease through its interaction with alpha synuclein said Shisheva As alpha synuclein Synphilin 1 is also entrapped in the abnormal Lewy body deposits Our study revealed that the ArPIKfyve Sac3 complex is an effective inhibitor of aggregate formation by Synphilin 1 In addition Shisheva s team found that excessive levels of Sac3 cause protein self aggregation and further facilitate the clumping by Synphilin 1

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17899 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    Announcements Archive Return to News List RoBUST 2015 Call for Seed Grant Proposals October 1 2015 Researchers of Biobehavioral health in Urban Settings Today or RoBUST are pleased to announce their 2015 seed grant program This program aims to provide research funds to foster transdisciplinary urban biobehavioral health pilot projects that involve collaboration between at least two RoBUST faculty members In particular it aims to stimulate early career urban biobehavioral

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17781 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    1507 from 1 30 to 3 30 p m A reception with refreshments will begin at 1 30pm followed by an introduction and presentation of the Zewail Medal at 2 p m in the EDC auditorium and concluding with Dr Sharpless s lecture at 2 30 p m The event is free and open to the public but registration is required To register visit http rsvp wayne edu zewail2015 Dr Sharpless is best known among synthetic chemists for discovering and developing many widely used catalytic oxidation processes especially the work for which he received a Nobel Prize in 2001 the first general methods for asymmetric oxidation the Sharpless reactions for asymmetric epoxidation 1980 dihydroxylation 1988 and aminohydroxylation 1996 Among a newer generation of scientists representing the entire chemical spectrum from chemical engineering and materials to chemical biology Sharpless is known for click chemistry a term he coined in 1998 Inspired by the complexity nature achieves from a handful of building blocks Sharpless started actively looking in the mid 90s for a way to discover new chemical connectivity and reactivity Click chemistry did not gain momentum until his group s discovery of CuAAC the copper catalyzed azide alkyne cycloaddition a near perfect reaction 2002 Recently the Sharpless group discovered SuFEx also near perfect for click chemistry In concert with the thiol ene reaction these three make click chemistry a far reaching method for discovery chemistry In 2011 Thomson Reuters named the top 100 chemists whose papers published in the first decade of the 21st Century achieved the highest citation impact scores Sharpless was number 4 Sharplesses mentors at Dartmouth BA 1963 Stanford PhD 1968 and postdoc and Harvard postdoc were Professors T A Spencer E E van Tamelen J P Collman and K Bloch respectively Before joining The Scripps Research Institute

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17670 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    study suggests that African Americans however are more receptive to gain framed messaging There may be a number of explanations for the difference between the two groups but Dr Lucas said the study indicates that with African Americans loss framed messaging may produce an inadvertent activation of negative emotion possibly including perceived racism that can impinge on how the message is received The study results he said suggest two things first that broadly construed messaging strategies should be carefully vetted before they are targeted across cultures Secondly the study indicates that emphasizing the positives of cancer screening may be a more successful messaging tactic with African Americans The message framing literature has suggested for years that loss frames are generally better at compelling cancer screening behavior but loss framed messages may be having the exact opposite effect on African Americans who thus far haven t been well attended to in the message framing literature Dr Lucas said Emphasizing bad things that could result from not being screened may not be an effective messaging strategy unless perhaps it is done in a way that seems culturally targeted to African Americans for example a loss framed message combined with a culturally targeted self control message Worldwide colorectal cancer is the third most common cancer in men and second most common in women with more than 1 million cases diagnosed annually African Americans have the highest rates of the disease and the highest death rate from colorectal cancer of any ethnic group in the United States Improved screening and screening rates could mitigate those rates but effective communication strategies are critical to boost screening numbers The study s coauthors include Lenwood Hayman Family Medicine and Public Health Sciences and also the Department of Psychology James Blessman M D M P H Family Medicine

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17611 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    The Great Lakes Water Agreement September 2 2015 The Office of the Vice President for Research is pleased to offer the Water Wayne seminar series Seminars are held on the dates noted in the below link from 2 30 to 4 00 pm in WSU s Welcome Center auditorium The seminars are free registration is requested Our first seminar is Thursday September 3 Our guest presenter is Rajesh Bejankiwar Scientific

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17571 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    September 2 2015 The Office of the Vice President for Research is pleased to announce the upcoming 2015 2016 Sustainability Wayne Seminar Series The seminars will be held on various Tuesday s throughout the school year from 2 30 to 4 p m and will be held in WSU s Welcome Center auditorium The series kicks off on September 8 2015 with guest speaker John Bradburn Global Manager for Waste

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17570 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    said Professor of Obstetrics and Gynecology Elizabeth Puscheck M D the grant s principal investigator at its inception Our program at Wayne State has received consistent funding since 1998 when the National Institutes of Health first saw a need for young investigators working in obstetrical and gynecological research That need continues today Dr Puscheck said Specifically there is a shortage of clinician scientists in the perinatal and women s health area That s where improved outcomes are going to come from said program recruiting officer Robert Sokol M D the John M Malone Jr M D Endowed Chair and director of the C S Mott Center for Human Growth and Development This grant is aimed at improving the situation by training young academicians to be successful clinician scientists In addition we are committed to helping relieve an even greater shortage of minority clinician scientists in our area The WSU department has held a national leadership role in research for more than 40 years Dr Sokol said boasting a cadre of doctoral degree researchers and funded clinician scientists We have always being in the top 10 and usually in the top three This is in part due to our department having one of only three research centers on the continent the Mott Center devoted to perinatal and maternal health research he said We have an excellent environment for this program as recognized by the review committee In addition we have a Ph D concentration in reproductive sciences with Physiology making obtaining a Ph D during the scholars program possible The most recent round of grant funding was highly competitive with fewer sites selected for the new period and only two candidates allowed per program In previous years each site was allowed three candidates I think that previous performance and ongoing commitment

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17498 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    to announce that the Veterinary Technology Program will begin classes for incoming first year students as well as returning second year students this fall semester First year students are currently being contacted to provide them with more details The Veterinary Technology Program is an Associate of Applied Science degree offered by Wayne County Community College District Wayne State University provides the curriculum personnel equipment and facilities for the program The

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=17468 (2016-02-13)
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