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  • News and Announcements Archive - Nano@Wayne - Division of Research
    Atherosclerosis can lead to serious problems including heart attack stroke or even death The team of researchers discovered that a unique combination of vitamin E isomers known as tocotrienols improved the patients lipid profiles The study Vitamin E tocotrienol supplementation improves lipid profiles in chronic hemodialysis patients was published in a recent issue of the journal Vascular Health Risk Management and showed that patients in the randomized double blind placebo controlled parallel trial who were given the vitamin E supplement had notable improvement in their lipid profiles compared to those given the placebo After 12 and 16 weeks of intervention the hemodialysis patients taking the Vitamin E supplements showed significant improvements in their blood lipid profiles said Pramod Khosla Ph D associate professor of nutrition food science in Wayne State University s College of Liberal Arts and Sciences Specifically their triglycerides were reduced and their HDL cholesterol levels increased as compared to the placebo group This study could potentially have positive clinical implications in the future for hemodialysis patients that need to improve their triglyceride and HDL levels but first these findings need to be verified in a much larger group of subjects Additionally we need to tease out the interactive effects of the tocotrienols with various medications that are routinely prescribed to these patients added Khosla Accelerated cardiovascular disease is a major problem in the end stage renal disease population and these findings may lead to new approaches to understanding its pathophysiology and to treatment commented James Sondheimer M D associate professor of internal medicine in Wayne State s School of Medicine A multicenter trial to confirm these findings and determine clinical significance is clearly called for Sondheimer was not involved in the study In addition to this study Khosla s research team is focused on dietary and lifestyle

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13233 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    levels Specifically the extracts significantly increased high density lipoprotein cholesterol HDL C aka good cholesterol and reduced non HDL cholesterol bad cholesterol and the ratio of total cholesterol HDL C despite the ongoing consumption of high fat food The test subjects in the recent study consumed a high fat diet for four weeks at which point they became hypercholesterolemic i e they had high plasma cholesterol levels Subsequently the animals were given the extracts for 0 untreated 3 7 10 14 and 21 days while still on the high fat diet The results indicated that the PAZ extracts may be a useful option for improving the plasma cholesterol profile despite the hypercholesterolemic state induced by a high fat diet Specifically bad cholesterol concentrations significantly decreased in all subjects consuming the PAZ extracts compared to those who were not treated Furthermore increased levels of good cholesterol could be seen as early as Day Three for that same group By Day 21 good cholesterol levels increased by 28 and bad cholesterol levels decreased by 30 Additionally metabolomics analysis was conducted to analyze the concentration of certain metabolites small molecules which are byproducts of normal metabolic functions in the blood Administering the PAZ extract correlated with significantly decreased levels of several metabolites that are independent predictors of increased risk of atherosclerosis and cardiovascular disease Gene expression analysis was also conducted to get a deeper insight into the increase in plasma HDL c levels Thus the expression levels mRNA of proteins involved in HDL c metabolism were evaluated By Day Ten subjects showed a threefold increase in the gene expression of APO A1 a major protein associated with the production of HDL particles the good cholesterol which increased sixfold by Day 21 To put this in perspective the benefit of raising HDL can be explained by examining how these good cholesterol particles function They play a key role in removing excess cholesterol from cell storage and transporting that cholesterol to the liver for excretion from the body said Amy Steffek Ph D HEPI Director of Research Development They also have other properties that promote and protect cardiovascular health and serve as an independent predictor of cardiovascular risk To simplify one can lower risk of cardiovascular disease by increasing levels of HDL cholesterol Given that cardiovascular disease is a leading cause of death in the US and other industrialized nations the effects of our algal extracts in improving good cholesterol and therefore cardiovascular health are significant and potentially wide reaching Whether the relationship between our bioactive extracts and increased HDL cholesterol is causal or correlative the studies conducted show an improved metabolic state despite the continuation of a high fat diet About Wayne State University Wayne State University is one of the nation s pre eminent public research universities in an urban setting Through its multidisciplinary approach to research and education and its ongoing collaboration with government industry and other institutions the university seeks to enhance economic growth and improve the quality of life in

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13141 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    Sciences led a large collaborative effort of physicists at the Fermi National Accelerator Laboratory Fermilab in Illinois reporting a bizarre social behavior of particles containing charm quarks an observation of charm mixing The result was published this month in Physical Review Letters the highly regarded journal for particle physics Figure 1 The decay of the D into a D0 and a soft low momentum pion The D0 then decays into a negative kaon and a positive pion This is called a right sign decay Another decay mode called a wrong sign which is very rare can occur In this mode the D0 decays into a positive kaon and a negative pion Figure 2 The ratio of the rare D0 decay mode K pi to a more common one K pi versus decay time measured in units of the D0 lifetime If the mixing process did not occur the ratio would remainunchanged with time The measured ratio includes decays from prompt and non prompt D0 mesons blue curve The ratio using only prompt decays is shown by the red curve Since the discovery of the charm quark in 1974 physicists have postulated a rare process in which a charm particle spontaneously changes into its antiparticle Evidence for this unique behavior was uncovered more than three decades later by experiments in the US and Japan However conclusive observation did not emerge until this year from the CERN laboratory in Switzerland and Fermilab in the U S Mattson and Karchin worked closely with team co leaders from Fermilab and the University of Siena in Italy Robert Harr Ph D and Alexey Petrov Ph D professors of physics and astronomy at Wayne State served as team advisors The charm mixing that has been observed could be due solely to known elementary particles but may

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13140 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    sores and ulcers Corneal complications include diabetic neuropathies and ocular complications that often lead to reduced vision or blindness A team of Wayne State University researchers recently developed several diabetic models to study impaired wound healing in diabetic corneas Using a genome wide cDNA array analysis the group identified genes their associated pathways and the networks affected by DM in corneal epithelial cells and their roles in wound closure Their findings may bring scientists one step closer to developing new treatments that may slow down or thwart the impact on vision The team led by Fu Shin Yu Ph D professor of ophthalmology and director of research at the Kresge Eye Institute has discovered transforming growth factor β TGFβ signaling as a major pathway affected by hyperglycemia in DM corneal epithelial cells In addition Yu and his team identified for the first time that wound induced upregulation of TGFβ3 is dampened by hyperglycemia and that by adding TGFβ3 to the wound epithelial wound closure was accelerated This discovery published online in the prestigious scientific journal Diabetes may provide new treatment options for diabetic wound healing in tissues such as the cornea and skin Delayed wound healing are major complications of diabetes often leading to severe end results such as diabetic ulcers losing a limb or going blind said Joan Dunbar Ph D associate vice president for technology commercialization at Wayne State University Dr Yu s discovery of the genome wide transcriptional analysis has allowed the development of composition and methods to treat negative effects of diabetes which may ultimately promote healing of wounds reduce the negative effects of diabetic neuropathies and promote the health of the eye and maintenance of eye sight in diabetics The findings in the cornea have a strong implication in the skin as they both have

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13085 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    in gender imbalanced fields The project Michigan Alliance for Graduate Education and the Professoriate is led by the University of Michigan in collaboration with Wayne State University Michigan State University Western Michigan University and Michigan Technological University The alliance aims to strengthen the academic identity of graduate students and postdoctoral fellows by improving their mentoring relationships and engaging them in interdisciplinary learning communities The alliance aims to improve mentoring of our students and fellows by providing new programs for our faculty in evidence based strategies for effective mentoring as well as design individual mentoring tailored to the discipline and circumstances of each pair of faculty and student or postdoc said Joseph Dunbar Ph D associate vice president for research and associate dean of the Graduate School at Wayne State University and principal investigator of Wayne State s part in the project In addition we will design interventions to engage our students and postdocs in learning communities that will aid them to develop their research ideas and share their ideas across disciplinary boundaries as well as engage in learning communities not only within their own institution but with others across the state The ultimate goal of the project is to increase the number of underrepresented minorities and women graduate students to complete doctoral degrees and ultimately guide them to pursue academic positions This project will move our respective institutions and others who will learn from the models we develop to address the urgent need to empower more of the nation s talented women and underrepresented minority college students to pursue scientific and academic careers said Dunbar This is a superb program for the next generation of scientists and academicians The project originally began in 2004 with partners UM MSU WSU and WMU Michigan Technological University joined the project in 2010 The

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13078 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    stand together as the University Research Corridor enrolling a quarter of the state s college students and conducting more than 2 billion annually in research and development One of the nation s top innovation clusters the URC helps bring some of the world s most talented people to our state and equips our own students to compete globally Federal dollars flowing to universities such as ours support well over half of America s scientific research and a large share of the R D that turns fundamental discoveries into innovative processes and products The talent we develop in our classrooms and laboratories accounts for an even greater share But like any other talent driven organization once a program or lab is closed it is difficult to restore Potential and opportunities are lost for years perhaps forever A recent nationwide survey of research universities shows that most of us already can point to cuts in research support by our funding agencies This threatened work affects vital sectors including medicine agriculture engineering and energy It impacts the careers of our research faculty recruitment of graduate and undergraduate students and relationships with external partners It threatens our communities and diminishes prospects for our nation s competitiveness in a world where others perceive an American lack of will Other nations are taking pages out of our playbook by investing more in research and higher education while we cede the initiative The nation has reached another point of decision If Congress can t stop digging this hole by Friday yet another round of across the board sequestration cuts takes effect in January That means deserving new research projects going unfunded and perhaps some existing programs gutted Promising young researchers could be cut loose program infrastructure would start to unravel and more hard won ground would be

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13037 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    the award for his outstanding work in the field of the humanities Port s book Conflict and Stability in the German Democratic Republic offers a careful analysis of life at the grass roots of East Germany Addressing the puzzling 40 year stability of the German Democratic Republic GDR he shows how communist officials maintained domestic peace through negotiation and compromise with those under their charge At the same time Port demonstrates how social frictions caused by the privileging of certain groups hindered potentially destabilizing challenges to the regime by undercutting solidarity among ordinary East Germans Instead of taking the usual approach of looking at the history of the German Democratic Republic Dr Port s book takes an alternative look at the collapse of the socialist state it grapples with the puzzle of regime stability and how the German Democratic Republic lasted for so long despite widespread social political and economic discontent and conflict at the grass roots said Marc Kruman Ph D chair of history at Wayne State University Port is currently the review editor of the German Studies Review and will begin serving in 2014 as the editor of the journal Central European History His research focuses on modern Germany and Europe communism and state socialism social protest popular resistance under autocratic regimes and comparative genocide He is currently writing What Germans Talk about When They Talk about Genocide a book that will explore German reactions to genocide in other parts of the world since 1945 with a special focus on Cambodia Rwanda and the Balkans The DAAD Prize aims to foster a new generation of American scholarship on Germany and encourage innovative contributions to the interdisciplinary scope of German studies said Kruman Dr Port s dedication to his field makes him most deserving of this prestigious award Port

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=13019 (2016-02-13)
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  • News and Announcements Archive - Nano@Wayne - Division of Research
    manage cancer and related conditions It has identified VPE001 a prodrug of EGCG with improved bioavailability and potency as its lead drug candidate expected to enter clinical development in 2015 Initial clinical indications may include the treatment of uterine fibroids and or delaying the progression of cancer in high risk early stage chronic lymphocytic leukemia patients My laboratory was the first to identify inhibition of proteasomal chymotrypsin like activity as an important mechanism of action of EGCG said Dou We also know that EGCG can affect albeit to a lesser extent other important pathways such as PI3K Akt mTOR signaling Viteava s drug candidates target diseases where these pathways are dysregulated I am very excited to work together with Viteava Pharmaceuticals to move towards the clinic drug candidates designed through a deep understanding of structure activity relationships involving the EGCG pharmacophore that my laboratory has researched for many years said Chan We have been working diligently to translate the well established health benefits of green tea and its major active ingredient EGCG to design commercially viable drug candidates Viteava Pharmaceuticals is a privately held start up drug development company established to commercialize this intellectual property portfolio The company s strategy focuses principally on clinical indications where green tea extracts have been demonstrated to elicit biological responses in human studies Viteava s drug candidates are designed to improve these treatment regimens and achieve better clinical outcomes while retaining a high level of safety By regulating multiple pathways important to the progression of diseases such as cancer Viteava s drug candidates are expected to provide advantages over more potent and more selective drugs that usually only elicit temporary responses together with a high level of toxicity Pou s research stemmed from a grant and administrative supplement of over 1 6 million from

    Original URL path: http://research.wayne.edu/nano/news_archive.php?id=12979 (2016-02-13)
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