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  • Biochemistry | UW-Madison
    gene encodes the enzyme SCD whose job is to synthesize fatty acids that are a major component of fat When we fed a starch and sugar rich diet to mice lacking SCD 1 in the liver the extra carbohydrates were broken down rather than being converted into fat and stored keeping the mice skinny Meanwhile control mice with normal gene activity grew plump on the same food High carbohydrate diets have become exceedingly common not only in western nations but also in the developing world as sugary ingredients like high fructose corn syrup have crept into all sorts of processed foods including soft drinks baked goods condiments even supposedly healthy items like low fat fruit yogurt What our team has now demonstrated is how those diets can act directly on a gene to boost fat synthesis and storage This current study builds on previous collaborative work in which we created mice that lacked SCD 1 everywhere in the body including the liver muscle brain pancreas and adipose tissue No matter how much they ate the mice didn t gain weight on either a high fat or a high carbohydrate diet The findings also highlight the central role of the enzyme

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/default.aspx (2013-05-02)
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  • Media Center | Biochemistry | UW-Madison
    journal covers models Molecular graphics processes graphs charts PowerPoint talks brochures flyers posters announcements and signs Digital Imaging Scanning reflective and transparent objects film and negatives and performing image retouching Technical Support By phone and in person explaining and answering how to questions on computers software and equipment Consulting Modifying existing digital files modifying customer generated digital files teaching software hardware and techniques Video Services Seminars meetings video and DVD creation storage and archive Digital Video Creating Editing and Manipulation Movies PowerPoint QuickTime and VRs Creating editing and manipulation of digital video Animations PowerPoint QuickTime Flash swf etc Prints Laser poster and digital photographic prints Photography Location Photography Studio Photography Portraits Programs and Technical Support Creating For We provide artistic and photographic interpretation of scientific data hypotheses and theories State of the art equipment and knowledge Fully digital Illustrator Photoshop scanning iPhoto PowerPoint Keynote Pymol DreamWeaver GoLive iWeb Acrobat Word iPod Quicktime Digital Video Final Cut Pro Desire to Learn D2L InDesign Printing Digital Photography Mac OS X Audio Visuals File formats and storage Web pages Web Design Illustrations Molecular Graphics Posters Animations Digital Videos Photographs Podcasts Graphs Charts Prints Models Slides Teaching Meetings Papers Books Presentations Talks Teaching Podcasts

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/medialab/default.aspx (2013-05-02)
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  • News 2013 | Biochemistry | UW-Madison
    Click here for more details April 30 2013 Laura Vanderploeg 2013 recipient of the CALS Excellence in Service Award Often the first contact of the department Laura provides illustrations webpage support data media photography and the department s annual newsletter She has a great ability to turn even the simplest not yet formulated idea into a beautiful presentation Click here for more details April 19 2013 Ron Raines Honored with Jeremy Knowles Award The Royal Society of Chemistry has named Professor Ron Raines as the winner of the 2013 Jeremy Knowles Award This annual award is to recognise and promote the importance of inter and multi disciplinary research between chemistry and the life sciences Click here for more details March 22 2013 W W Cleland Memorial Events W Wallace Mo Steenbock Symposium 2014 A symposium in honor and celebration of Mo s lasting contributions to mechanistic enzymology is planned for early spring of 2014 The exact date and place will be announced in the near future The symposium will take place over three days with fifteen speakers an opening reception and a banquet A poster session is also planned W Wallace Mo Cleland Memorial Fund A Fund has been established at the University of Wisconsin Foundation to honor Mo Cleland s contributions to the Department of Biochemistry fund number 12157778 or click here for fund link Although the exact use of these funds is yet to be defined it is planned that they will reflect his great generosity of time towards graduate students and postdocs Celebration of Life for W Wallace Mo Cleland There will be a celebration of life for Mo Cleland in the Tripp Commons of the Memorial Union May 11 from 3 to 5 pm March 19 2013 Hector DeLuca Named Fellow of the 2012 National Academy

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/news/ (2013-05-02)
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  • Faculty | Biochemistry | UW-Madison
    vitamin A metabolite all trans retinoic acid in nervous system development the therapeutic use of vitamin A and D analogs Michael M Cox Email Molecular biology and enzymology of genetic recombination and DNA repair Elizabeth A Craig Email Folding and remodeling of proteins in the cell the function of molecular chaperones Brian G Fox Email Biochemical catalytic and spectroscopic studies of redox active enzymes protein engineering Paul D Friesen Email Molecular biology of eukaryotic DNA viruses regulation of gene expression programmed cell death apoptosis and retrotransposons Colleen E Hayes Email Molecular mechanisms that regulate immune responses Hazel M Holden Email Structure and function of enzymes Aaron Hoskins Email Elucidating biochemical mechanisms in eukaryotic RNA metabolism with chemistry biology and single molecule analysis Laura L Kiessling Email Biomolecular recognition processes the chemistry and biology of protein saccharide interactions Judith Kimble Email Molecular regulation of animal development Robert Landick Email RNA polymerase structure function regulation of transcript elongation in bacteria and humans John L Markley Email NMR spectroscopy and its biological applications structure function relationships in proteins stable isotope assisted multinuclear magnetic resonance spectroscopy processing and analysis of multi dimensional NMR data structural genomics metabolomics Thomas F J Martin Email Mechanisms of hormone action signal transduction and second messengers regulation of hormone and neurotransmitter secretion inositol phospholipid biochemistry Julie Mitchell Email Predictive models of molecular interactions and protein design James M Ntambi Email Genetic Regulation of Metabolism The Stearoyl CoA Desaturase Genes David J Pagliarini Email Mitochondrial biogenesis and metabolism cell signaling proteomics Ann C Palmenberg Email Molecular biology of RNA picornaviruses protein translation proteolytic processing RNA synthesis viral pathogenesis viral vaccines vaccine vectors computer based sequence analysis J Wesley Pike Email Transcriptional mechanisms of steroid hormone action in the skeleton Ronald T Raines Email Chemical biology protein chemistry and engineering enzymology

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/faculty/ (2013-05-02)
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  • Undergraduate Program | Biochemistry | UW-Madison
    basic science which has as its goal an explanation of life processes in physical and chemical terms It deals with the chemical and physical properties of living matter and with the chemical changes occurring in living matter This includes the properties and chemical changes in genes DNA generally referred to as molecular biology The major in biochemistry is designed to fit the needs of the student who wishes to terminate his her training at the B S level as well as those students planning on graduate or professional school study The degree will serve as an excellent background for medical school or veterinary school admission This major also provides an excellent background for graduate study in biochemistry or other allied fields such as biology bacteriology genetics molecular biology or oncology The basic requirements for the degree include courses in biology and general organic quantitative and physical chemistry Depending on his her particular interest the student can concentrate on electives in either of these areas to lead to a degree that contains as much chemistry as a chemistry major or that is more complete in the biological sciences The Biochemistry Department allows undergraduate majors in the department to continue beyond the sophomore year only if they have maintained a grade point average of at least 2 5 for their first two years Many opportunities for laboratory research experience are available on this campus for undergraduate students and such experience is strongly encouraged Independent study courses and senior thesis complement and extend these experiences Research experience is viewed favorably by employers and admission committees for graduate and professional schools Graduates in biochemistry are in demand for interesting jobs as participants in research groups in hospitals medical schools and academic institutions as well as a large number of different government laboratories and research

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/undergraduate_program/ (2013-05-02)
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  • PALS Home | Biochemistry | UW-Madison
    Evening Event April 16 2013 7 p m Workshops April 16 17 2013 in the afternoons Location WID 330 North Orchard Street map 11th Annual UW Madison Science Expeditions Friday April 5 Sunday April 7 2013 Science Expeditions is an annual event that welcomes the community to campus and promotes the understanding and appreciation of science and how science works among the public It also helps students at all levels develop important communication skills and scientist to showcase their research to the public It s a great opportunity to convey the wonders of science and advance the Wisconsin Idea Postdoctoral Career Development Conference Saturday April 6 2013 The UW Madison Graduate School is pleased to invite you to take part in a dynamic professional development opportunity open exclusively to UW Madison postdoctoral scholars This year s conference focuses on career planning strategies tailored to postdoctoral scholars and includes opportunities to interact with other postdocs and with experienced professionals in a variety of fields Creating a New Mindset to Explore Careers Outside of the Academy Thursday March 21 2013 Jobs in academia are just the tip of the iceberg Today s economy demands a broader perspective toward finding the right livelihood At this special webinar for graduate students Brooks will discuss the mindsets and actions needed to succeed in your search for a meaningful career The live webinar presentation will be followed by a Q A session A small reception with food and drinks will take place after the event All attendees are welcome There is limited space so registration is required Please register here PALS Seminar Series 2012 2013 UW Professional Development Calendar Series of interest 1 Biotech Happy Hour Past PALS Poster Session and Mixer 10 25 This is an event open to ALL postdocs Wisconsin Science Festival 9

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/pals/ (2013-05-02)
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  • Biochemistry Courses | Biochemistry | UW-Madison
    simulations Designed for advanced undergraduates and beginning graduate students in the biological sciences Prerequisites Concurrent or prior biochemistry calculus and freshman physics or equivalent 651 BIOCHEMICAL METHODS Sample Syllabus Fall Spring 3 cr Lectures and Lab Introduction to modern biochemical laboratory techniques For advanced undergraduates biochemistry and other majors and graduate students not majoring in biochemistry Prerequisites Chemistry 221 and Biochem 501 or equivalent 660 BIOCHEMICAL TECHNIQUES Fall 2 cr Survey of modern biochemical techniques Prerequisites 2 Semesters organic chemistry physical chemistry Biochem 601 or concurrent registration and consent of instructor 665 BIOPHYSICAL CHEMISTRY Also Chemistry 665 Fall Spring 4 cr Lectures and discussions Biochem 665 taught together with the advanced honors undergraduate course Chem 565 develops the principles of solution thermodynamics and chemical kinetics and applies this quantitative framework to discuss experimental data and analysis of the thermodynamics driving forces coupled conformational changes etc and mechanisms of biochemical processes involving proteins lipids and nucleic acids in solution Applications include protein folding nucleic acid helix formation micelle formation ligand binding cooperative binding and other assembly processes effects of water salts other solutes temperature and pressure on biochemical processes protein nucleic acid interactions and enzyme catalysis Weekly problem sets develop these applications Typical enrollment fall semester is 20 25 grad students and 75 85 undergrads 665 students are expected to have some previous background in physical chemistry as well as the 565 prerequisites 681 682 SENIOR HONORS THESIS For Honors Biochemistry majors only 3 cr Prerequisites Senior standing and consent of instructor 691 692 SENIOR THESIS 2 cr Prerequisites Senior standing and consent of instructor 699 SPECIAL PROBLEMS 1 4 cr Prerequisites Senior standing and consent of instructor 701 PROFESSIONAL RESPONSIBILITY Sample Syllabus Fall 1 cr Training for the practical aspects of being a scientist Will cover ethics peer review grant writing science communication career alternatives paper writing experimental design research documentation science funding academic private interface scientific fraud and more Prerequisite Admission to the IPiB graduate program 702 BIOCHEMICAL MECHANISMS OF REGULATION IN THE CELL Spring 3 cr Understanding biochemical mechanisms that drive the functioning of eucaryotic cells Topics to be covered include protein folding and proteolysis translocation to through organelles cellular cytoskeleton cell division and cell cell signaling with a goal of integrating the basic biochemical interactions common to these diverse cellular processes Prerequisites Biochem 501 507 or equivalent 703 TOPICS IN EUKARYOTIC REGULATION Also Genetics 703 Sample Syllabus Spring 2 cr Focuses on design and interpretation of experiments addressing molecular and genetic mechanisms of eukaryotic regulation Intended for first year graduate students with a firm knowledge of basic biochemistry prokaryotic molecular biology and molecular genetics Prerequisites Biochem 612 or equivalent and consent of instructor 704 CHEMICAL BIOLOGY Fall 2 cr Structure and function of proteins nucleic acids and carbohydrates application of organic chemistry to problems in cell biology Prerequisites Biochem 501 or equivalent 1 year of organic chemistry and consent of instructor 710 EXPLORING BIOCHEMICAL FUNCTIONS OF MACROMOLECULES Sample Syllabus Spring 2 cr Special topics of current interest

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/courses/course_description.aspx (2013-05-02)
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  • Current Seminars | Biochemistry | UW-Madison
    Richard Vallee Columbia University Role of Microtubule Motor Proteins in Brain Developmental Disease Biochemistry Colloquium Feb 11 Stephen Withers University of British Columbia New Access to Complex Glycoconjugates Through Engineering and Evolution of Glycosyltransferases and Glycosynthases Biochemistry Colloquium Feb 12 Rebecca Terns University of Georgia Athens RNA guided Defense in Bacteria RNA Maxi Group Feb 18 Hana El Samad U C S F From Synthetic Biology to Systems Analyses and Back Probing the Organizational Principles of Cellular Stress Responses Biochemistry Colloquium Feb 25 Patrick Loria Yale University The Role of Millisecond Loop Motions in Enzyme Function Biochemistry Colloquium Mar 4 David Barondeau Texas A M University Frataxin Activation of the Human Fe S Assembly Complex Biochemistry Colloquium Mar 11 Pablo Sobrado Virginia Tech Everson Lecture Mechanistic and Structural Studies of Flavoenzymes in Siderophore and Galactofuranose Biosynthesis Biochemistry Colloquium Mar 18 Peter Burgers Washington University Iron sulfur Clusters in DNA Replication and Mutagenesis Biochemistry Colloquium Mar 25 Zan Luthey Schulten University of Illinois at Urbana Champaign CANCELLED Biochemistry Colloquium Mar 26 Sarah Woodson Johns Hopkins University RNA Folding Catalysis and Assembly into RNPs RNA Maxi Group Apr 1 Feng Guo U C L A An Essential Role of Heme in MicroRNA Maturation Biochemistry Colloquium Apr 8 Oleg Tsodikov University of Michigan Exploring and exploiting novel Mycobacterium tuberculosis targets Biochemistry Colloquium Apr 9 Steven McKnight UT Southwestern Medical Center RNA Granules and Their Assembly RNA Maxi Group Apr 22 Seung Kim HHMI Stanford University School of Medicine Using Stem Cells and Developmental Biology to Elucidate Regulatory Networks Controlling Pancreas Organogenesis and Diseases Biochemistry Colloquium Apr 29 Tom Kirchhausen Harvard Medical School Dynamics of Endocytosis Biochemistry Colloquium May 6 Jared Rutter University of Utah Good and Bad Growth The Virtues and Vices of Mitochondria and Metabolism Biochemistry Colloquium May 13 Steve Gygi Harvard

    Original URL path: http://wwwprod.biochem.wisc.edu/biochem/seminars/ (2013-05-02)
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